The repair of bone defects remains a major clinical challenge because none available
reconstruction methods and biomaterials have been proved completely satisfactory. As a …

Introduction: Vascularization remains an obstacle to engineering of larger volume bone
tissues. Our aim was to induce axial vascularization in a processed bovine cancellous bone …

Abstract Tissue Engineering (TE) and Regenerative Medicine (RM) have gained much
popularity because of the tremendous prospects for the care of patients with tissue and …

The aim of this project was to construct vascularized tissue‐engineered living bone with an
autologous vascular network by means of a rabbit bioreactor in vivo. The key components of …

The repair of bone defects poses a great challenge for reconstructive surgeons. Although
the development of tißsue engineering has exhibited promise in replacing damaged bone …

It is a common treatment strategy in the clinic to transplant a vascularized bone flap for a
large bone defect. But it is difficult for peripheral blood vessels to grow into the central region …

This article describes the prefabrication of a vascularized bone graft composed of
autologous particulate cancellous bone and marrow (PCBM), a vessel bundle, and a …

The bone defect caused by fracture, bone tumor, infection, and other causes is not only a
problematic point in clinical treatment but also one of the hot issues in current research. The …

Editorial vascularization is the key challenge in tissue engineering (not only in bone
engineering)[10]. Vascularization can either be achieved by an extrinsic or an intrinsic …

During the last decades, a range of excellent and promising strategies in Bone Tissue
Engineering have been developed. However, the remaining major problem is the lack of …