Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies

R Yan, R Wang, B Ju, J Yu, Y Zhang, N Liu, J Wang… - Cell research, 2021 - nature.com
Neutralizing monoclonal antibodies (nAbs) to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) represent promising candidates for clinical intervention against …

Neutralizing antibodies for the prevention and treatment of COVID-19

L Du, Y Yang, X Zhang - Cellular & molecular immunology, 2021 - nature.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) initiates the infection
process by binding to the viral cellular receptor angiotensin-converting enzyme 2 through …

Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD

JM Errico, H Zhao, RE Chen, Z Liu, JB Case, M Ma… - Cell Reports, 2021 - cell.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
necessitated the rapid development of antibody-based therapies and vaccines as …

Structural basis of a human neutralizing antibody specific to the SARS-CoV-2 spike protein receptor-binding domain

M Yang, J Li, Z Huang, H Li, Y Wang, X Wang… - Microbiology …, 2021 - Am Soc Microbiol
The emerging new lineages of severe acute respiratory syndrome coronavirus-2 (SARS-
CoV-2) have marked a new phase of coronavirus disease 2019 (COVID-19). Understanding …

Perspectives on the development of neutralizing antibodies against SARS-CoV-2

M Ho - Antibody therapeutics, 2020 - academic.oup.com
SARS-CoV-2 gains entry to human cells through its spike (S) protein binding to angiotensin-
converting enzyme 2 (ACE2). Therefore, the receptor binding domain (RBD) of the S protein …

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

Z Lv, YQ Deng, Q Ye, L Cao, CY Sun, C Fan, W Huang… - Science, 2020 - science.org
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health …

Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain

X Chi, X Liu, C Wang, X Zhang, X Li, J Hou… - Nature …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads worldwide and
leads to an unprecedented medical burden and lives lost. Neutralizing antibodies provide …

Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective

Y Huang, H Sun, H Yu, S Li, Q Zheng… - Antibody …, 2020 - academic.oup.com
The rapid emergence of Coronavirus disease-2019 (COVID-19) caused by severe acute
respiratory syndrome 2 coronavirus (SARS-CoV-2) as a pandemic that presents an urgent …

Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals

SJ Zost, P Gilchuk, JB Case, E Binshtein, RE Chen… - BioRxiv, 2020 - biorxiv.org
The COVID-19 pandemic is a major threat to global health for which there are only limited
medical countermeasures, and we lack a thorough understanding of mechanisms of …

Structural basis of SARS-CoV-2 and SARS-CoV antibody interactions

E Gavor, YK Choong, SY Er, H Sivaraman… - Trends in …, 2020 - cell.com
The 2019 coronavirus pandemic remains a major public health concern. Neutralizing
antibodies (nAbs) represent a cutting-edge antiviral strategy. We focus here on severe acute …