Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters

BWY Mok, H Liu, S Deng, J Liu, AJ Zhang… - Communications …, 2021 - nature.com
Emerging variants of SARS-CoV-2 have been shown to rapidly replace original circulating
strains in humans soon after they emerged. There is a lack of experimental evidence to …

The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model

M Cochin, L Luciani, F Touret, JS Driouich… - Communications …, 2022 - nature.com
Abstract Late 2020, SARS-CoV-2 Alpha variant emerged in United Kingdom and gradually
replaced G614 strains initially involved in the global spread of the pandemic. In this study …

Transmissibility and pathogenicity of SARS-CoV-2 variants in animal models

YI Kim, MAB Casel, YK Choi - Journal of Microbiology, 2022 - Springer
Abstract As of February 2022, SARS-CoV-2 is still one of the most serious public health
threats due to its high mortality rate and rapid spread of novel variants. Since the first …

Impact of reinfection with SARS-CoV-2 omicron variants in previously infected hamsters

N Shiwa-Sudo, Y Sakai, N Iwata-Yoshikawa… - Journal of …, 2023 - Am Soc Microbiol
The diversity of SARS-CoV-2 mutations raises the possibility of reinfection of individuals
previously infected with earlier variants, and this risk is further increased by the emergence …

The SARS-CoV-2 B. 1.351 variant can transmit in rats but not in mice

C Zhang, H Cui, E Li, Z Guo, T Wang, F Yan… - Frontiers in …, 2022 - frontiersin.org
Previous studies have shown that B. 1.351 and other variants have extended the host range
of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to mice. Sustained …

Replicative fitness of a SARS-CoV-2 20I/501Y. V1 variant from lineage B. 1.1. 7 in human reconstituted bronchial epithelium

F Touret, L Luciani, C Baronti, M Cochin, JS Driouich… - MBio, 2021 - Am Soc Microbiol
Since its emergence in 2019, circulating populations of the new coronavirus (CoV)
continuously acquired genetic diversity. At the end of 2020, a variant named 20I/501Y. V1 …

[HTML][HTML] Increased pathogenicity and aerosol transmission for one SARS-CoV-2 B. 1.617. 2 Delta variant over the wild-type strain in hamsters

X Zhang, S Chen, Z Cao, Y Yao, J Yu, J Zhou, G Gao… - Virologica Sinica, 2022 - Elsevier
During the two-year pandemic of coronavirus disease 2019 (COVID-19), its causative agent,
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been evolving. SARS …

SARS-CoV-2 spike D614G variant exhibits highly efficient replication and transmission in hamsters

BWY Mok, CJ Cremin, SY Lau, S Deng, P Chen… - bioRxiv, 2020 - biorxiv.org
SARS-CoV-2 causes disease varying in severity from asymptomatic infections to severe
respiratory distress and death in humans. The viral factors which determine transmissibility …

[HTML][HTML] The G614 pandemic SARS-CoV-2 variant is not more pathogenic than the original D614 form in adult Syrian hamsters

CB Stauft, CZ Lien, P Selvaraj, S Liu, TT Wang - Virology, 2021 - Elsevier
Dynamic tracking of variant frequencies among viruses circulating in the global pandemic
has revealed the emergence and dominance of a D614G mutation in the SARS-CoV-2 spike …

SARS-CoV-2 variants Alpha, Beta, Delta and Omicron show a slower host cell interferon response compared to an early pandemic variant

L Laine, M Skön, E Väisänen, I Julkunen… - Frontiers in …, 2022 - frontiersin.org
Since the start of the pandemic at the end of 2019, arising mutations in SARS-CoV-2 have
improved its transmission and ability to circumvent the immunity induced by vaccination and …