[PDF][PDF] Cytokine storm

M Gaestel, AR Nebreda, MB Yaffe - 2021 - dspace.mit.edu
To the Editor: In their review article on cytokine storm, Fajgenbaum and June (Dec. 3 issue)
1 include a discussion of signaling by mitogenactivated protein kinase (MAPK), nuclear …

Treating exuberant, non-resolving inflammation in the lung; Implications for acute respiratory distress syndrome and COVID-19

DW Gilroy, RPH De Maeyer, M Tepper… - Pharmacology & …, 2021 - Elsevier
While COVID-19, the disease driven by SARS-CoV-2 has ignited interest in the host immune
response to this infection, it has also highlighted the lack of treatment options for the …

Correction: the signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
After online publication of the article, 1 the editor noticed that Figs. 1 and 4 were produced
with the assistance of Servier Medical Art (https://smart. servier. com) without citation. The …

Machine learning identifies ponatinib as a potent inhibitor of SARS-CoV2-induced cytokine storm

M Chan, S Vijay, MJ McElrath, EC Holland, TS Gujral - bioRxiv, 2021 - biorxiv.org
Abstract Although 15-20% of COVID-19 patients experience hyper-inflammation induced by
massive cytokine production, cellular triggers of this process and strategies to target them …

[PDF][PDF] Janus Family kinase (JAK) inhibitors in HLH and severe COVID‐19

RA Wilcox - 2020 - deepblue.lib.umich.edu
After its emergence in Wuhan, China, the rapid transmission of a novel betacoronavirus,
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), led to a worldwide …

Review on therapeutic targets for COVID-19: insights from cytokine storm

ML de Mélo Silva Júnior, LMA de Souza… - Postgraduate …, 2021 - academic.oup.com
Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been
caused the greatest pandemic of our century. Many of the deaths related to it are due to a …

Approaches to the potential therapy of COVID-19: a general overview from the medicinal chemistry perspective

JC Menéndez - Molecules, 2022 - mdpi.com
In spite of advances in vaccination, control of the COVID-19 pandemic will require the use of
pharmacological treatments against SARS-CoV2. Their development needs to consider the …

Off-label therapy targeting pathogenic inflammation in COVID-19

L Romani, C Tomino, P Puccetti, E Garaci - Cell death discovery, 2020 - nature.com
The world is facing a pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) for which no proven specific therapies are available other than supportive ones …

Use of Janus kinase inhibitors in COVID-19: a prospective observational series in 522 individuals

O Melikhov, T Kruglova, K Lytkina… - Annals of the …, 2021 - ard.bmj.com
Janus kinase (JAK) inhibitors for the treatment of hospitalised patients with COVID-19 have
been extensively studied. Initially, at the start of the pandemic outside of China, baricitinib …

Treatment of the cytokine storm in COVID-19: review of clinical pharmacology

AN Sapriati, F Rahmawati… - JSFK (Jurnal Sains …, 2023 - jsfk.ffarmasi.unand.ac.id
The cause of the COVID-19 pandemic can be attributed to the Acute Respiratory Syndrome
Virus-2 (SARS-CoV-2). COVID-19 manifests with severe symptoms in the upper respiratory …