CCL17 exerts neuroprotection through activation of CCR4/mTORC2 axis in microglia after subarachnoid haemorrhage in rats

A Zhang, Y Liu, H Xu, Z Zhang, X Wang… - Stroke and Vascular …, 2023 - svn.bmj.com
Background and purpose CC motif chemokine ligand 17 (CCL17) presents an important role
in immune regulation, which is critical in the pathophysiology of brain injury after …

Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in …

S Deng, P Jin, P Sherchan, S Liu, Y Cui… - Journal of …, 2021 - Springer
Background Intracerebral hemorrhage (ICH), a devastating subtype of stroke, is associated
with high mortality and morbidity. Neuroinflammation is an important factor leading to ICH …

Maraviroc, an inhibitor of chemokine receptor type 5, alleviates neuroinflammatory response after cerebral Ischemia/reperfusion injury via regulating MAPK/NF-κB …

B Chen, P Cao, X Guo, M Yin, X Li, L Jiang… - International …, 2022 - Elsevier
Neuroinflammation is a key factor that contributes to the secondary damage after cerebral
ischemia/reperfusion (CI/R) injury. Chemokine receptor type 5 (CCR5) has shown its pro …

[HTML][HTML] Targeting CCL20 inhibits subarachnoid hemorrhage-related neuroinflammation in mice

LS Liao, MW Zhang, YJ Gu, XC Sun - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
Recent evidence suggests that CC chemokine ligand 20 (CCL20) is upregulated after
subarachnoid hemorrhage (SAH). Here, we investigated the functions of CCL20 in SAH …

Knockdown of CC chemokine receptor 5 (CCR5) is protective against cerebral ischemia and reperfusion injury

E Constanza Gomez Victoria… - Current …, 2017 - ingentaconnect.com
Background: Stroke is the second leading cause of death and a major cause of disability of
adults worldwide. Inflammatory processes are known to contribute to the pathophysiology of …

Microglia-derived CCL20 deteriorates neurogenesis following intraventricular hemorrhage

N Yao, Y Li, J Han, S Wu, X Liu, Q Wang, Z Li… - Experimental …, 2023 - Elsevier
Intraventricular hemorrhage (IVH) commonly occurs as an extension of intracerebral
hemorrhage (ICH) into the brain ventricular system, leading to worse outcomes without …

Inhibition of CCR1 attenuates neuroinflammation via the JAK2/STAT3 signaling pathway after subarachnoid hemorrhage

Q Tian, Y Li, S Feng, C Liu, Y Guo, G Wang… - International …, 2023 - Elsevier
Background and purpose Neuroinflammation is an important mechanism underlying brain
injury caused by subarachnoid hemorrhage (SAH). CC chemokine receptor type 1 (CCR1) …

[HTML][HTML] Brain-derived CCR5 contributes to neuroprotection and brain repair after experimental stroke

S Ping, X Qiu, M Kyle, LR Zhao - Aging and disease, 2021 - ncbi.nlm.nih.gov
Abstract Chemokine (CC motif) receptor 5 (CCR5) is expressed not only in the immune cells
but also in cerebral cells such as neurons, glia, and vascular cells. Stroke triggers high …

Astrocyte-derived CCL7 promotes microglia-mediated inflammation following traumatic brain injury

J Xue, Y Zhang, J Zhang, Z Zhu, Q Lv, J Su - International …, 2021 - Elsevier
Microglia are immune cells of the central nervous system that mediate neuroinflammation. It
is widely known that microglia-mediated inflammation in the brain contribute to the …

Chemokine receptor 7 mediates miRNA‐182 to regulate cerebral ischemia/reperfusion injury in rats

Q Wang, S Xu, B Wang, Y Qin, Y Ji… - CNS Neuroscience …, 2023 - Wiley Online Library
Abstract Aims Chemokine receptor 7 (CXCR7) exerts protective effects on the brain.
MicroRNAs (miRNAs) are involved in cerebral ischemia/reperfusion (I/R) injury, but their …