The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

R Klein, V Nanduri, S Jing, F Lamballe, P Tapley… - Cell, 1991 - cell.com
Summary trkB is a tyrosine protein kinase gene highly related to trk, a proto-oncogene that
encodes a receptor for nerve growth factor (NGF) and neurotrophin-3(NT-3). t&B expression …

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

C Cordon-Cardo, P Tapley, S Jing, V Nanduri… - Cell, 1991 - cell.com
The product of the trk proto-oncogene encodes a receptor for nerve growth factor (NGF).
Here we show that NGF is a powerful mitogen that can induce resting NIH 3T3 cells to enter …

The trkB tyrosine protein kinase is a receptor for neurotrophin-4

R Klein, F Lamballe, S Bryant, M Barbacid - Neuron, 1992 - cell.com
Neurotrophin-4 is a novel member of the nerve growth factor family of neurotrophins recently
isolated from Xenopus and viper DNA. We now report that the Xenopus NT-4 protein(XNT4) …

The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines

DM Loeb, J Maragos, D Martin-Zanca, MV Chao… - Cell, 1991 - cell.com
The trk tyrosine kinase proto-oncogene product gp140p'“'o” k binds nerve growth factor
(NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine …

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

F Lamballe, R Klein, M Barbacid - Cell, 1991 - cell.com
We report the isolation and molecular characterization of t&C, a new member of the trk family
of tyrosine protein kinase genes. t&C is preferentially expressed in the brain. In situ …

trkC encodes multiple neurotrophin‐3 receptors with distinct biological properties and substrate specificities.

F Lamballe, P Tapley, M Barbacid - The EMBO Journal, 1993 - embopress.org
The trkC gene product gp145trkC is a high affinity signaling receptor for neurotrophin‐3 (NT‐
3), a member of the NGF family of neurotrophic factors. We now report that trkC encodes at …

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

SP Squinto, TN Stitt, TH Aldrich, S Davis, SM Blanco… - Cell, 1991 - cell.com
A variety of findings seem to functionally link brainderived neurotrophic factor (BDNF))'and
neurotrophin3 (NT-3), while distinguishing both of these factors from the third member of the …

Alternative forms of rat TrkC with different functional capabilities

DM Valenzuela, PC Maisonpierre, DJ Glass, E Rojas… - Neuron, 1993 - cell.com
We have identified transcripts encoding several different forms of rat TrkC, a member of the
Trk family of receptor tyrosine kinases that serves as a receptor for neurotrophin-3. Some …

Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling

FF Eide, ER Vining, BL Eide, K Zang… - Journal of …, 1996 - Soc Neuroscience
trkB encodes a receptor tyrosine kinase activated by three neurotrophins—brain-derived
neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4/5. In vivo, three isoforms of …

A splice variant of the neurotrophin receptor trkB with increased specificity for brain‐derived neurotrophic factor.

C Strohmaier, BD Carter, R Urfer, YA Barde… - The EMBO …, 1996 - embopress.org
The trkB gene codes for a receptor tyrosine kinase, which is essential for the development of
the peripheral nervous system. This receptor can be activated by three different …