Vertical and horizontal gene transfer tradeoffs direct plasmid fitness
Plasmid fitness is directed by two orthogonal processes—vertical transfer through cell
division and horizontal transfer through conjugation. When considered individually …
division and horizontal transfer through conjugation. When considered individually …
Conjugation dynamics depend on both the plasmid acquisition cost and the fitness cost
H Prensky, A Gomez‐Simmonds… - Molecular systems …, 2021 - embopress.org
Plasmid conjugation is a major mechanism responsible for the spread of antibiotic
resistance. Plasmid fitness costs are known to impact long‐term growth dynamics of …
resistance. Plasmid fitness costs are known to impact long‐term growth dynamics of …
Methods to study fitness and compensatory adaptation in plasmid-carrying bacteria
J DelaFuente, J Rodriguez-Beltran… - Horizontal Gene Transfer …, 2020 - Springer
Mobile genetic elements such as plasmids mediate horizontal gene transfer in prokaryotes,
promoting bacterial adaptation and evolution. Despite the potential advantages conferred by …
promoting bacterial adaptation and evolution. Despite the potential advantages conferred by …
Why do plasmids manipulate the expression of bacterial phenotypes?
K Billane, E Harrison, D Cameron… - … Transactions of the …, 2022 - royalsocietypublishing.org
Conjugative plasmids play an important role in bacterial evolution by transferring niche-
adaptive traits between lineages, thus driving adaptation and genome diversification. It is …
adaptive traits between lineages, thus driving adaptation and genome diversification. It is …
Environmental and genetic determinants of plasmid mobility in pathogenic Escherichia coli
Plasmids are key vehicles of horizontal gene transfer (HGT), mobilizing antibiotic resistance,
virulence, and other traits among bacterial populations. The environmental and genetic …
virulence, and other traits among bacterial populations. The environmental and genetic …
Tradeoff between lag time and growth rate drives the plasmid acquisition cost
M Ahmad, H Prensky, J Balestrieri, S ElNaggar… - Nature …, 2023 - nature.com
Conjugative plasmids drive genetic diversity and evolution in microbial populations. Despite
their prevalence, plasmids can impose long-term fitness costs on their hosts, altering …
their prevalence, plasmids can impose long-term fitness costs on their hosts, altering …
Growth‐stage‐dependent regulation of conjugation
Plasmid conjugation is a driving force behind the spread of antibiotic resistance genes.
While problematic for medical purposes, conjugation can be used for delivery of target …
While problematic for medical purposes, conjugation can be used for delivery of target …
Mobile compensatory mutations promote plasmid survival
The global dissemination of plasmids encoding antibiotic resistance represents an urgent
issue for human health and society. While the fitness costs for host cells associated with …
issue for human health and society. While the fitness costs for host cells associated with …
Plasmid and clonal interference during post horizontal gene transfer evolution
Plasmids are nucleic acid molecules that can drive their own replication in a living cell. They
can be transmitted horizontally and can thrive in the host cell to high‐copy numbers. Plasmid …
can be transmitted horizontally and can thrive in the host cell to high‐copy numbers. Plasmid …
Increased copy number couples the evolution of plasmid horizontal transmission and plasmid-encoded antibiotic resistance
T Dimitriu, AC Matthews… - Proceedings of the …, 2021 - National Acad Sciences
Conjugative plasmids are mobile elements that spread horizontally between bacterial hosts
and often confer adaptive phenotypes, including antimicrobial resistance (AMR). Theory …
and often confer adaptive phenotypes, including antimicrobial resistance (AMR). Theory …