Hepatic ischemia/reperfusion injury is caused primarily by the products of neutrophils
recruited into the liver after reperfusion. The mediators responsible for the development of …

Hepatic ischemia and reperfusion causes neutrophil‐dependent liver injury. Although the
mechanisms of ischemia/reperfusion‐induced liver neutrophil recruitment are somewhat …

The liver is highly susceptible to a number of pathological insults, including
ischemia/reperfusion injury. We have previously employed an animal model of hepatic …

Accumulating evidence suggests that IL-1β plays a pivotal role in the pathophysiology of
hepatic ischemia–reperfusion (I/R) injury; however, the mechanism by which I/R triggers IL …

Ischemia/reperfusion injury of the liver has two distinct phases that contribute to hepatocyte
damage. The acute phase is characterized by Kupffer cell production of reactive oxygen …

Neutrophils play a major role in the hepatic microvasculature following liver ischemia and
reperfusion (I/R). Leukocyte cytokine chemoattractants (chemokines) are produced by …

Hepatic ischemia/reperfusion injury is a clinically important problem. While the mechanisms
of the initial event and subsequent neutrophil‐dependent injury are somewhat understood …

BACKGROUND: Hepatic ischemia/reperfusion has been shown to cause both local hepatic
and distant (such as lung) organ injury caused by accumulation of neutrophils in the local …

The mechanisms by which polymorphonuclear neutrophils (PMNs) are recruited by the
ischemic and reperfused liver are still unknown. The purpose of this study was to determine …

Tumor necrosis factor (TNF) is released during hepatic ischemia/reperfusion (I/R) and plays
an important role in the ensuing neutrophil-mediated lung and liver injury. Since TNF is not a …