Therapeutic drug monitoring (TDM) provides valuable guidance for dose adjustment of
antibiotics, immunosuppressives, antiepileptics, and other drugs, but its use for traditional …

Most anticancer drugs are characterised by a steep dose–response relationship and narrow
therapeutic window. Inter-individual pharmacokinetic (PK) variability is often substantial. The …

Most of oral targeted therapies are tyrosine kinase inhibitors (TKIs). Oral administration
generates a complex step in the pharmacokinetics (PK) of these drugs. Inter-individual PK …

There is accumulating evidence for potential benefits of therapeutic drug monitoring (TDM)
in the treatment of cancer with tyrosine kinase inhibitors (TKIs). Relationships between …

Therapeutic drug monitoring (TDM) can be defined as the measurement of drug in biological
samples to individualise treatment by adapting drug dose to improve efficacy and/or reduce …

The selection of an appropriate therapy and dosing regimen is a significant challenge in the
treatment of cancer. Although there are recommended standardized chemotherapy …

The therapeutic activity of drugs can be optimized by establishing an individualized dosage,
based on the measurement of the drug concentration in the serum, particularly if the drugs …

Therapeutic drug monitoring is not routinely used for chemotherapy agents. There are
Several reasons, but one major drawback is the lack of established therapeutic …

Cytotoxic drugs are highly efficacious and also have low therapeutic index. A great degree
of caution needs to be exercised in their usage. To optimize the efficacy these drugs need to …

Several anticancer drugs display characteristics that make them suitable candidates for
therapeutic drug monitoring (TDM), including substantial pharmacokinetic variability and a …