The different cell types of an organism share the same DNA, but during cell differentiation
their genomes undergo diverse structural and organizational changes that affect gene …

Understanding how chromatin is organized within the nucleus and how this 3D architecture
influences gene regulation, cell fate decisions and evolution are major questions in cell …

The relation between alterations in chromatin structure and changes in gene expression
during cell differentiation has served as a paradigm to understand the link between genome …

Animal development depends on not only the linear genome sequence that embeds millions
of cis-regulatory elements, but also the three-dimensional (3D) chromatin architecture that …

Mammalian genomes encode genetic information in their linear sequence, but appropriate
expression of their genes requires chromosomes to fold into complex three-dimensional …

Genomes have complex three-dimensional architectures. The recent convergence of
genetic, biochemical, biophysical, and cell biological methods has uncovered several …

The linear sequence of eukaryotic genomes is arranged in a specific manner within the
three-dimensional nuclear space. Interactions between distant sites partition the genome …

To accommodate genomes in the limited space of the cell nucleus and ensure the correct
execution of gene expression programs, genomes are packaged in complex fashion in the …

The three-dimensional architecture of the genome affects genomic functions. Multiple
genome architectures at different length scales, including chromatin loops, domains …

An expansive functionality and complexity has been ascribed to the majority of the human
genome that was unanticipated at the outset of the draft sequence and assembly a decade …