During cerebral ischemia, angiogenesis occurs inside and around the infarcted area. The
growth of new blood vessels may contribute to a better outcome after stroke due to …

Platelet derived growth factor (PDGF)-B plays a neuroprotective role in brain damages,
including ischemic stroke. It has been suggested recently that PDGF receptor β (PDGFRβ) …

Background and Purpose Growth factors control two important processes in infarcted tissue,
ie, angiogenesis and gliosis. We recently reported that transforming growth factor-β1 (TGF …

Fibrosis is concomitant with repair processes following injuries in the central nervous system
(CNS). Pericytes are considered as an origin of fibrosis-forming cells in the CNS. Here, we …

Although platelet-derived growth factors (PDGFs) and receptors (PDGFRs) are abundantly
expressed in the central nervous system, their functions largely remain elusive. We …

Our previous study on the ischemia-induced expression of platelet-derived growth factor
(PDGF)-B chain in the rat brain prompted us to examine expression of PDGF β-receptor in …

To elucidate the role of the platelet-derived growth factor (PDGF)–B chain in the brain, we
examined its expression in rat brains with focal ischemia. Focal ischemia was induced by …

Central nervous system (CNS) pericytes have been recognized as an indispensable
component of the neurovascular unit. The expression of platelet-derived growth factor …

The neuroprotective agents and induction of endogenous neurogenesis remain to be the
urgent issues to be established for the care of cerebral stroke. Platelet-derived growth factor …

Blood–brain barrier (BBB) dysfunction underlies the pathogenesis of many neurological
diseases. Platelet-derived growth factor receptor-alpha (PDGFRα) induces hemorrhagic …