Individuals from different populations vary considerably in their susceptibility to immune-
related diseases. To understand how genetic variation and natural selection contribute to …

Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …

Immune response is one of the functions that have been more strongly targeted by natural
selection during human evolution. The evolutionary genetic dissection of the immune system …

Pathogens have always been a major cause of human mortality, so they impose strong
selective pressure on the human genome. Data from population genetic studies, including …

Highlights•Host and pathogen genomes can be analyzed jointly.•Host and pathogen co-
evolution results in signals of positive selection.•Recent adaptation to pathogens generates …

Highlights•Demographic history and natural selection shaped human genome
diversity.•Infections represented a major environmental selective pressure for human …

Background Humoral immune responses to infectious agents or vaccination vary
substantially among individuals, and many of the factors responsible for this variability …

There is a genetic basis to the most common immune‐mediated diseases. Identifying
disease susceptibility genes, however, has been a challenge. Only a few genes have been …

The mammalian immune system packs serious punch against infection but can also cause
harm: for example, coronavirus disease 2019 (COVID-19) made headline news of the …

Autoimmune diseases display a high degree of comorbidity within individuals and families,
suggesting shared risk factors. Over the past 15 years, genome-wide association studies …