Fibrosis by common usage in the pathological and clinical literature is the end result of a
healing process and synonymous with scarring. We would argue that its use to describe a …

There has been ongoing controversy related to what differentiates normal lung repair and
fibrosis. For example, the current prevailing concept has been that idiopathic forms of …

Context.—Idiopathic pulmonary fibrosis is a progressive, fatal lung disease occurring in
older individuals. Despite 50 years of accrued data about the disease, little progress has …

Pulmonary fibrosis is characterized by an increase in lung matrix and alterations in the
numbers and spatial relationships of lung parenchymal cells. The increase in matrix results …

Many lung diseases result in fibrotic remodelling. Fibrotic lung disorders can be divided into
diseases with known and unknown aetiology. Among those with unknown aetiology …

Two elements are involved in the repair of tissue injury, the replacement of damaged cells
and the filling of spaces that result from tissue loss. The lung, unlike other organs, has an …

Lung research supported by the National Heart, Lung, and Blood Institute (NHLBI) has had
important outcomes that have resulted in an infinitely better understanding of how …

Although the precise definition of pulmonary fibrosis depends to some extent on one's
discipline, for the purposes of this review it will be somewhat loosely defined as “abnormal …

This review discusses current knowledge of the involvement of the alveolar epithelium in
tissue remodelling during fibrogenesis. The purpose of the present paper is to give an …

The mechanisms of pulmonary fibrosis are complex, and several hypotheses have been put
forward to explain how fibrosis develops. It was long thought that inflammation was a key …