Identification of unique venous thromboembolism-susceptibility variants in African-Americans
JA Heit, SM Armasu, BM McCauley… - Thrombosis and …, 2017 - thieme-connect.com
To identify novel single nucleotide polymorphisms (SNPs) associated with venous
thromboembolism (VTE) in African-Americans (AAs), we performed a genome-wide …
thromboembolism (VTE) in African-Americans (AAs), we performed a genome-wide …
Whole exome sequencing in thrombophilic pedigrees to identify genetic risk factors for venous thromboembolism
MLR Cunha, JCM Meijers, FR Rosendaal, AH Vlieg… - PLoS …, 2017 - journals.plos.org
Background Family studies have shown a strong heritability component for venous
thromboembolism (VTE), but established genetic risk factors are present in only half of VTE …
thromboembolism (VTE), but established genetic risk factors are present in only half of VTE …
Is there still room for additional common susceptibility alleles for venous thromboembolism?
DA Trégouët, A Delluc, A Roche… - … of Thrombosis and …, 2016 - Wiley Online Library
Essentials Genetic architecture of venous thromboembolism (VTE) remains to be fully
disentangled. 11 newly discovered candidate polymorphisms were genotyped in 3019 VTE …
disentangled. 11 newly discovered candidate polymorphisms were genotyped in 3019 VTE …
Causal associations between cardiovascular risk factors and venous thromboembolism
M Hu, X Li, Y Yang - Seminars in Thrombosis and Hemostasis, 2023 - thieme-connect.com
Objective The aim of the study is to assess the causal effects of cardiovascular risk factors on
venous thromboembolism (VTE) and its subtypes including deep vein thrombosis (DVT) and …
venous thromboembolism (VTE) and its subtypes including deep vein thrombosis (DVT) and …
[PDF][PDF] Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism
M Germain, DI Chasman, H De Haan, W Tang… - The American Journal of …, 2015 - cell.com
Venous thromboembolism (VTE), the third leading cause of cardiovascular mortality, is a
complex thrombotic disorder with environmental and genetic determinants. Although several …
complex thrombotic disorder with environmental and genetic determinants. Although several …
Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis
Thrombotic diseases are among the leading causes of morbidity and mortality in the world.
To add insights into the genetic regulation of thrombotic disease, we conducted a genome …
To add insights into the genetic regulation of thrombotic disease, we conducted a genome …
Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism
We report a genome-wide association study of venous thromboembolism (VTE)
incorporating 81,190 cases and 1,419,671 controls sampled from six cohorts. We identify 93 …
incorporating 81,190 cases and 1,419,671 controls sampled from six cohorts. We identify 93 …
[HTML][HTML] Genetic variation within the anticoagulant, procoagulant, fibrinolytic and innate immunity pathways as risk factors for venous thromboembolism
JA Heit, JM Cunningham, TM Petterson… - Journal of thrombosis …, 2011 - Elsevier
Background: Venous thromboembolism (VTE) is highly heritable (estimated heritability [h 2]=
0.62) and likely to be a result of multigenic action. Objective: To systematically test variation …
0.62) and likely to be a result of multigenic action. Objective: To systematically test variation …
Proteome-wide mendelian randomization identifies causal plasma proteins in venous thromboembolism development
Genome-wide association studies (GWAS) have identified numerous risk loci for venous
thromboembolism (VTE), but it is challenging to decipher the underlying mechanisms. We …
thromboembolism (VTE), but it is challenging to decipher the underlying mechanisms. We …