[HTML][HTML] Arginase: An emerging and promising therapeutic target for cancer treatment
F Niu, Y Yu, Z Li, Y Ren, Z Li, Q Ye, P Liu, C Ji… - Biomedicine & …, 2022 - Elsevier
Arginase is a key hydrolase in the urea cycle that hydrolyses L-arginine to urea and L-
ornithine. Increasing number of studies in recent years demonstrate that two mammalian …
ornithine. Increasing number of studies in recent years demonstrate that two mammalian …
Arginine signaling and cancer metabolism
Simple Summary In this review, we describe arginine's role as a signaling metabolite,
epigenetic regulator and mitochondrial modulator in cancer cells, and summarize recent …
epigenetic regulator and mitochondrial modulator in cancer cells, and summarize recent …
Arginine dependence of tumor cells: targeting a chink in cancer's armor
Arginine, one among the 20 most common natural amino acids, has a pivotal role in cellular
physiology as it is being involved in numerous cellular metabolic and signaling pathways …
physiology as it is being involved in numerous cellular metabolic and signaling pathways …
Targeting arginine metabolism pathway to treat arginine-dependent cancers
F Qiu, J Huang, M Sui - Cancer letters, 2015 - Elsevier
The significant disparities in metabolism between tumor and normal cells have inspired the
development of metabolism-based anti-tumor therapeutics. Arginine is a semi-essential …
development of metabolism-based anti-tumor therapeutics. Arginine is a semi-essential …
Molecular basis and current strategies of therapeutic arginine depletion for cancer
Renewed interest in the use of therapeutic enzymes combined with an improved knowledge
of cancer cell metabolism, has led to the translation of several arginine depletion strategies …
of cancer cell metabolism, has led to the translation of several arginine depletion strategies …
Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer
Y Ino, R Yamazaki-Itoh, S Oguro, K Shimada… - PloS one, 2013 - journals.plos.org
An adequate level of arginine in the tissue microenvironment is essential for T cell activity
and survival. Arginine levels are regulated by the arginine-catabolizing enzyme, arginase …
and survival. Arginine levels are regulated by the arginine-catabolizing enzyme, arginase …
Myeloid cell-derived arginase in cancer immune response
TM Grzywa, A Sosnowska, P Matryba… - Frontiers in …, 2020 - frontiersin.org
Amino acid metabolism is a critical regulator of the immune response, and its modulating
becomes a promising approach in various forms of immunotherapy. Insufficient …
becomes a promising approach in various forms of immunotherapy. Insufficient …
Replacing Mn2+ with Co2+ in Human Arginase I Enhances Cytotoxicity toward l-Arginine Auxotrophic Cancer Cell Lines
Replacing the two Mn2+ ions normally present in human Arginase I with Co2+ resulted in a
significantly lowered KM value without a concomitant reduction in k cat. In addition, the pH …
significantly lowered KM value without a concomitant reduction in k cat. In addition, the pH …
Arginine and arginases modulate metabolism, tumor microenvironment and prostate cancer progression
Arginine availability and activation of arginine-related pathways at cancer sites have
profound effects on the tumor microenvironment, far beyond their well-known role in the …
profound effects on the tumor microenvironment, far beyond their well-known role in the …
Deprivation of arginine by recombinant human arginase in prostate cancer cells
EC Hsueh, SM Knebel, WH Lo, YC Leung… - Journal of hematology & …, 2012 - Springer
Background Recombinant human arginase (rhArg) has been developed for arginine
deprivation therapy in cancer, and is currently under clinical investigation. During pre …
deprivation therapy in cancer, and is currently under clinical investigation. During pre …