The concept of cell replacement to compensate for cell loss and restore functionality has
entered several disease entities including neurodegenerative disorders. Recent clinical …

Stem cell replacement has emerged as the novel therapeutic strategy for Parkinson's
disease (PD). Control of motor behavior is lost in PD due to the selective degeneration of …

Parkinson's disease (PD) is a neurodegenerative disease characterised by a loss of
midbrain dopaminergic (DA) neurons. Transplantation of DA neurons represents a …

Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The
onset of PD is usually after the age of 50. Clinical symptoms of PD are not manifested until …

Embryonic stem (ES) cells are genetically normal, continuous cell lines that can give rise to
a variety of somatic cells in culture. These include the midbrain dopaminergic neurons, a …

Parkinson's disease (PD) is characterized by tremor, rigidity, and bradykinesia. PD is caused
mainly by depletion of the nigrostriatal pathway. Conventional medications such as …

Motor dysfunctions in Parkinson's disease are considered to be primarily due to the
degeneration of dopaminergic neurons in the substantia nigra pars compacta …

The rationale behind the use of cells as therapeutic modalities for neurodegenerative
diseases in general, and in Parkinson's disease (PD) in particular, is that they will improve …

Current therapeutic approaches for Parkinson's disease (PD) provide symptomatic relief but
none of them change the course of disease. There is therefore a clear need for regenerative …

Treating neurodegenerative diseases with cell transplantation has been within reach since
the first pioneering clinical trials in which dopamine neuron progenitors from the fetal brain …