Despite massive investments in drug research and development, the significant decline in
the number of new drugs approved or translated to clinical use raises the question, whether …

Combination therapies for various cancers have been shown to increase efficacy, lower
toxicity, and circumvent resistance. However, despite the promise of combinatorial therapies …

Cancer cells contain multiple genetic changes in cell signaling pathways that drive
abnormal cell survival, proliferation, invasion, and metastasis. Unfortunately, patients treated …

Identification of novel targets is a critical first step in the drug discovery and development
process. Most diseases such as cancer, metabolic disorders, and neurological disorders are …

High-throughput drug screening has facilitated the discovery of drug combinations in cancer.
Many existing studies adopted a full matrix design, aiming for the characterization of drug …

The cellular network and its environment govern cell and organism behavior and are
fundamental to the comprehension of function, misfunction and drug discovery. Over the last …

The complexity and flexibility of cellular architectures is increasingly recognized by
impressive progress on the side of molecular analytics, ie proteomics, genomics and …

Drug combinations, offering increased therapeutic efficacy and reduced toxicity, play an
important role in treating multiple complex diseases. Yet, our ability to identify and validate …

Combination drug therapy is a widely used paradigm for managing numerous human
malignancies. In cancer treatment, additive and/or synergistic drug combinations can …

Drug combinations are a promising strategy to overcome the compensatory mechanisms
and unwanted off-target effects that limit the utility of many potential drugs. However …