Background Combination of different agents is widely used in clinic to combat complex
diseases with improved therapy and reduced side effects. However, the identification of …

Rapid advances in pharmaceutical sciences have brought ever-increasing interests in
combined therapies for better clinical efficacy and safety, especially in cases of complicated …

Highlights•Currently a vast heterogeneity in synergistic drug action scoring and analysis
exists.•Novel cellular models offer robust ways to identify relevant combination …

Genome-Wide Association Studies (GWAS), whole genome sequencing, and high-
throughput omics techniques have generated vast amounts of genotypic and molecular …

Introduction: Polypharmacology has emerged as an essential paradigm for modern drug
discovery process. Multiple lines of evidence suggest that agents capable of modulating …

Recent studies have highlighted the importance of interconnectivity in a large range of
molecular and human disease-related systems. Network medicine has emerged as a new …

Motivation Drug combinations that simultaneously suppress multiple cancer driver signaling
pathways increase therapeutic options and may reduce drug resistance. We have …

Drug combinations have been widely applied to treat complex diseases, like cancer, HIV
and cardiovascular diseases. One of the most important characteristics for drug …

The pharmaceutical industry faces unprecedented pressures based largely on the inability
to bring sufficient new medicines to market. The high failure rate of drug candidates in …

At the core of complex and multifactorial human diseases, such as cancer, metabolic
syndrome, or neurodegeneration, are multiple players that cross‐talk in robust biological …