Rational design of multi-targeted drug combinations is a promising strategy to tackle the
drug resistance problem for many complex disorders. A drug combination is usually …

Mechanistic PKPD models are now advocated not only by academic and industrial
researchers, but also by regulators. A recent development in this area is based on the …

Diseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's
diseases), and of malignancy (cancers) have complex and varied causative factors. Modern …

Current cancer therapy includes a variety of strategies that can comprise only one type of
treatment or a combination of multiple treatments. Chemotherapy is still the gold standard for …

Simple Summary Current treatments for complex diseases, including cancer, are generally
characterized by high toxicity due to their low selectivity for target cells. Moreover, patients …

Drug combination therapy has become a promising therapeutic strategy for cancer
treatment. While high-throughput drug combination screening is effective for identifying …

Efforts to construct therapeutically useful models of biological systems require large and
diverse sets of data on functional connections between their components. Here we show …

Drug combinations are becoming a standard treatment of many complex diseases due to
their capability to overcome resistance to monotherapy. In the current preclinical drug …

Multicomponent therapies, originating through deliberate mixing of drugs in a clinical setting,
through happenstance, and through rational design, have a successful history in a number …

Many successful drugs bind to and modulate multiple targets in vivo. Successfully navigating
protein–ligand polypharmacology will be a crucial and increasingly utilized component of …