Polypharmacology offers a model for the way drug discovery must evolve to develop
therapies most suited to treating currently incurable diseases. It is driven by a worldwide …

A crucial question that must be addressed in the drug development process is whether the
proposed therapeutic target will yield the desired effect in the clinical population …

Neuropharmacology had several major past successes, but the last few decades did not
witness any leap forward in the drug treatment of brain disorders. Moreover, current drugs …

Drug-combination data portals have recently been introduced to mine huge amounts of
pharmacological data with the aim of improving current chemotherapy strategies. However …

Drug action depends not only on the direct consequences of the interaction between the
drug and its target but also on other consequences within the complex physiological system …

Combination chemotherapy is considered the “norm” in cancer chemotherapy. While the
development of classical combination regimens took into account factors such as single …

A recent trend in drug development is to identify drug combinations or multi-target agents
that effectively modify multiple nodes of disease-associated networks. Such …

High‐throughput experimental techniques for generating genomes, transcriptomes,
proteomes, metabolomes, and interactomes have provided unprecedented opportunities to …

Systems biology is in an exponential development stage in recent years and has been
widely utilized in biomedicine to better understand the molecular basis of human disease …

Small molecules often affect multiple targets, elicit off‐target effects, and induce genotype‐
specific responses. Chemical genetics, the mapping of the genotype dependence of a small …