Publisher Summary There are three distinctly different approaches to multitarget therapy.
Clinicians have treated unresponsive patients by combining therapeutic mechanisms with …

Ligand-and structure-based drug design approaches complement phenotypic and target
screens, respectively, and are the two major frameworks for guiding early-stage drug …

Background: This white paper arises from two workshops held at the NIH in 2008 and late
2010 with participation from academia, industry and government (http://meetings. nigms. nih …

Background Network science is already making an impact on the study of complex systems
and offers a promising variety of tools to understand their formation and evolution in many …

Combinatorial therapies have been recently proposed to improve the efficacy of anticancer
treatment. The SynergyFinder R package is a software used to analyze pre-clinical drug …

Rational design of drug combinations has become a promising strategy to tackle the drug
sensitivity and resistance problem in cancer treatment. To systematically evaluate the pre …

Drug combinations have been proposed as a promising therapeutic strategy to overcome
drug resistance and improve efficacy of monotherapy regimens in cancer. This strategy aims …

Combinatorial therapies that target multiple pathways have shown great promises for
treating complex diseases. DrugComb (https://drugcomb. org/) is a web-based portal for the …

Combinations of therapies are being actively pursued to expand therapeutic options and
deal with cancer's pervasive resistance to treatment. Research efforts to discover effective …

Systems pharmacology is an emerging approach that sets out to use quantitative concepts
rooted in the synergy between modeling and simulation on one hand and large‐scale data …