Interventions to reduce the cardiotoxicity of doxorubicin are clinically relevant.
Pharmacological preconditioning mimicking ischemic preconditioning has been …

Doxorubicin (DOX) is an anthracycline antibiotic that is widely used as a chemotherapeutic
agent. However, usefulness of this agent is limited due to its cardiotoxic effects. The aim of …

An investigation was performed in the rat to assess the cardiotoxic effects of exogenous
doxorubicinol compared with those induced by an equimolar dose of its parent drug …

Aim Chemotherapy with doxorubicin is limited by cardiotoxicity. Free radical generation and
mitochondrial dysfunction are thought to contribute to doxorubicin-induced cardiac failure. In …

Objective: Long-term co-administration of morphine and calcium channel antagonists
(CCAs) is likely in some clinical conditions. Reciprocal interactions during chronic …

Aim: Short-time models (STM) to study the cardiotoxicity (acute or chronic) of doxorubicin in
rats are of interest to assess protective interventions and pathways. STM promotes more …

Objective The objective of this study was to investigate, in a rabbit model, the
cardioprotective eff ect of morphine preconditioning against cardiac remodelling. Methods …

The therapeutic usefulness of doxorubicin, an antineoplastic drug, is limited by its
cardiotoxicity whose mechanism is as yet unknown. Several hypotheses have been …

Purpose: To determine the effects of amifostine on an isolated perfused rat-heart model and
its protective activity with regard to cardiotoxic doxorubicin perfusion. Methods: Langendorff …

Selective cardiotoxicity of doxorubicin remains a significant and dose-limiting clinical
problem. The mechanisms involved have not been fully defined but may involve the …