The bone defect caused by fracture, bone tumor, infection, and other causes is not only a
problematic point in clinical treatment but also one of the hot issues in current research. The …

Bone is one of the most vascular network-rich tissues in the body and the vascular system is
essential for the development, homeostasis, and regeneration of bone. When segmental …

With the continuous development of bone tissue engineering, a variety of emerging bone
graft materials provided various methods for repairing bone defects. Early and rapid …

Biomaterial based reconstruction is still the most commonly employed method of small bone
defect reconstruction. Bone tissue-engineered techniques are improving, and adjuncts such …

There is a profound need for orthopaedic grafting strategies due to various trauma and
musculoskeletal diseases. Tissue engineering offers a promising avenue to develop viable …

Tissue engineering uses various approaches to restore bone loss and heal critical-size
defects resulting from trauma, infection, tumor resection or other musculoskeletal diseases …

Bone tissue is a highly vascularized tissue and concomitant development of the vascular
system and mineralized matrix requires a synergistic interaction between osteogenesis and …

Editorial vascularization is the key challenge in tissue engineering (not only in bone
engineering)[10]. Vascularization can either be achieved by an extrinsic or an intrinsic …

Conspectus In the rapidly evolving landscape of regenerative medicine, the field of bone
tissue engineering stands as a beacon of innovative progress, pushing the boundaries of …

Significant advances have been made in bone tissue engineering (TE) in the past decade.
However, classical bone TE strategies have been hampered mainly due to the lack of …