Male sex is a risk factor for progression of diabetic kidney disease, but the reasons for this predilection are unclear. Here, we demonstrate that cell sex and sex hormones alter the …
SC Freixas, O Zaslaver, C Pastrello… - Journal of the …, 2021 - journals.lww.com
Background: Diabetic kidney disease (DKD) is the major cause of end-stage kidney disease. Male sex is a risk factor for DKD, but the reasons for this predilection are unclear. We …
SC Freixas, JAD Van, CM McEvoy… - Journal of the …, 2020 - journals.lww.com
Background: Male sex predisposes to diabetic kidney disease (DKD). We uncovered androgen-induced perturbations in kidney metabolic proteins that may drive faster DKD …
Diabetic kidney disease (DKD) is the main cause of chronic kidney disease (CKD) and progresses faster in males than in females. We identify sex-based differences in kidney …
EF Carney - Nature Reviews Nephrology, 2024 - nature.com
The epidemiology of diabetic kidney disease (DKD) differs by sex, with a greater risk of kidney failure in men. New data suggest that sex differences in kidney metabolism may …
N Ziller, R Kotolloshi, M Esmaeili, M Liebisch… - Cells, 2020 - mdpi.com
While females are less affected by non-diabetic kidney diseases compared to males, available data on sex differences in diabetic nephropathy (DN) are controversial. Although …
C Greenhill - Nature Reviews Endocrinology, 2024 - nature.com
Diabetic kidney disease (DKD) is a common complication of diabetes mellitus and can lead to chronic kidney failure. However, prevention and treatment options are fairly limited. In …
F Piani, I Melena, KL Tommerdahl, N Nokoff… - Journal of diabetes and …, 2021 - Elsevier
Sexual dimorphism may play a key role in the pathogenesis of diabetic kidney disease (DKD) and explain differences observed in disease phenotypes, responses to interventions …
BD Shepard - American Journal of Physiology-Renal …, 2019 - journals.physiology.org
Type 1 and type 2 diabetes, along with their accompanying hyperglycemia, are associated with a multitude of comorbidities including the development of diabetic kidney disease …