Cell Sex and Sex Hormones Modulate Kidney Glucose and Glutamine Metabolism in Health and Diabetes: TH-PO765

SC Freixas, M Kotlyar, CM McEvoy… - Journal of the …, 2022 - journals.lww.com
Background: Diabetic Kidney Disease (DKD) is recongnized as the leading cause of
Chronic Kidney Disease (CKD). Male sex is a risk factor for CKD, and is generally …

Cell Sex and Sex Hormones Modulate Kidney Glucose and Glutamine Metabolism in Health and Diabetes

S Clotet-Freixas, O Zaslaver, C Pastrello, M Kotlyar… - BioRxiv, 2021 - biorxiv.org
Male sex is a risk factor for progression of diabetic kidney disease, but the reasons for this
predilection are unclear. Here, we demonstrate that cell sex and sex hormones alter the …

Cell Sex and Sex Hormones Regulate Kidney Metabolism of Glucose and Glutamine: Implications for Diabetic Kidney Disease: PO0731

SC Freixas, O Zaslaver, C Pastrello… - Journal of the …, 2021 - journals.lww.com
Background: Diabetic kidney disease (DKD) is the major cause of end-stage kidney disease.
Male sex is a risk factor for DKD, but the reasons for this predilection are unclear. We …

Cell Sex and Sex Hormones Modulate Glucose and Glutamine Kidney Metabolism: Implications for Diabetic Kidney Disease: PO0938

SC Freixas, JAD Van, CM McEvoy… - Journal of the …, 2020 - journals.lww.com
Background: Male sex predisposes to diabetic kidney disease (DKD). We uncovered
androgen-induced perturbations in kidney metabolic proteins that may drive faster DKD …

Sex differences in kidney metabolism may reflect sex-dependent outcomes in human diabetic kidney disease

S Clotet-Freixas, O Zaslaver, M Kotlyar… - Science translational …, 2024 - science.org
Diabetic kidney disease (DKD) is the main cause of chronic kidney disease (CKD) and
progresses faster in males than in females. We identify sex-based differences in kidney …

[引用][C] Sex differences in kidney metabolism and DKD

EF Carney - Nature Reviews Nephrology, 2024 - nature.com
The epidemiology of diabetic kidney disease (DKD) differs by sex, with a greater risk of
kidney failure in men. New data suggest that sex differences in kidney metabolism may …

Sex differences in diabetes-and TGF-β1-induced renal damage

N Ziller, R Kotolloshi, M Esmaeili, M Liebisch… - Cells, 2020 - mdpi.com
While females are less affected by non-diabetic kidney diseases compared to males,
available data on sex differences in diabetic nephropathy (DN) are controversial. Although …

Sex differences in diabetic kidney disease explained

C Greenhill - Nature Reviews Endocrinology, 2024 - nature.com
Diabetic kidney disease (DKD) is a common complication of diabetes mellitus and can lead
to chronic kidney failure. However, prevention and treatment options are fairly limited. In …

Sex-related differences in diabetic kidney disease: A review on the mechanisms and potential therapeutic implications

F Piani, I Melena, KL Tommerdahl, N Nokoff… - Journal of diabetes and …, 2021 - Elsevier
Sexual dimorphism may play a key role in the pathogenesis of diabetic kidney disease
(DKD) and explain differences observed in disease phenotypes, responses to interventions …

Sex differences in diabetes and kidney disease: mechanisms and consequences

BD Shepard - American Journal of Physiology-Renal …, 2019 - journals.physiology.org
Type 1 and type 2 diabetes, along with their accompanying hyperglycemia, are associated
with a multitude of comorbidities including the development of diabetic kidney disease …