Improved understanding of the pathophysiology of sepsis: Setting the scene for potential novel adjunctive therapies

JM Chausse, L Malekele, F Paruk - Southern African Journal of Critical …, 2018 - ajol.info
The occurrence of sepsis in the critically ill population is a dreaded phenomenon when
taking into consideration the devastating complications associated with the disease. Despite …

Pathophysiology of sepsis

PD Gopalan - Southern African Journal of Anaesthesia and …, 2022 - sajaa.co.za
The increasing incidence of sepsis and its related problems, and the associated
unacceptably high mortality rates continue despite a wider public awareness of the disease …

Emerging therapeutic targets for sepsis

EW Tindal, BE Armstead, SF Monaghan… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: Sepsis is characterized by a dysregulated host response to infection. Sepsis-
associated morbidity/mortality demands concerted research efforts toward therapeutic …

[图书][B] Handbook of sepsis

WJ Wiersinga, CW Seymour - 2018 - Springer
Sepsis is one of the most common deadly diseases. Despite its remarkable incidence, and
despite the progress which has been made in understanding this complex syndrome, for …

Pathogenetic aspects of sepsis and possible targets for adjunctive therapy

O Rigato, E Silva, EG Kallas… - Current Drug Targets …, 2001 - ingentaconnect.com
The outcome of patients with sepsis arises from multiple factors affecting both the host and
the invading microorganisms. Age, presence of underlying disease, source of infection and …

Therapeutic interventions in sepsis: current and anticipated pharmacological agents

P Shukla, GM Rao, G Pandey, S Sharma… - British journal of …, 2014 - Wiley Online Library
Sepsis is a clinical syndrome characterized by a multisystem response to a pathogenic
assault due to underlying infection that involves a combination of interconnected …

Sepsis-follow the guidelines

W Lance Michell - Southern African Journal of Critical Care (Online), 2018 - scielo.org.za
Sepsis is an ever-present foe in the intensive care unit (ICU). Sepsis and septic shock
account for 11% of admissions to general ICUs.[1] Mortality exceeds 10% for sepsis, and sits …

Is a different view on the pathophysiology of sepsis the key for novel therapeutic options?

N Schlegel, S Flemming, M Meir, CT Germer - Der Chirurg, 2014 - Springer
Sepsis remains a critical problem in virtually all fields of clinical medicine. Despite intensive
scientific and clinical efforts no significant progress has emerged in the fight against sepsis …

New strategies for treatment of sepsis

A Mirijello, A Tosoni… - Medicina, 2020 - mdpi.com
Sepsis represents a major global health concern and is one of the most feared
complications for hospitalized patients, being the cause, directly or indirectly, of about half of …

[图书][B] Clinical and pathophysiological aspects of sepsis

A Linnér - 2014 - search.proquest.com
Severe sepsis and septic shock represent challenging problems for the health care system.
Despite adequate antibiotics and modern intensive care, severe sepsis is associated with a …