Lisinopril increases lung ACE2 levels and SARS-CoV-2 viral load and decreases inflammation but not disease severity in experimental COVID-19
Y Silva-Santos, RL Pagni, THM Gamon… - Frontiers in …, 2024 - frontiersin.org
COVID-19 causes more severe and frequently fatal disease in patients with pre-existing
comorbidities such as hypertension and heart disease. SARS-CoV-2 virus enters host cells …
comorbidities such as hypertension and heart disease. SARS-CoV-2 virus enters host cells …
Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors—lessons from available evidence and insights into COVID-19
H Kai, M Kai - Hypertension Research, 2020 - nature.com
The rapid spread of a novel coronavirus, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has led to an ongoing pandemic of coronavirus disease 2019 (COVID-19) …
(SARS-CoV-2), has led to an ongoing pandemic of coronavirus disease 2019 (COVID-19) …
Oral lisinopril raises tissue levels of ACE2, the SARS-CoV-2 receptor, in healthy male and female mice
SD Brooks, RL Smith, AS Moreira… - Frontiers in …, 2022 - frontiersin.org
Angiotensin-converting enzyme 2 (ACE2) is the established cellular receptor for SARS-CoV-
2. However, it is unclear whether ACE1 inhibitors (eg, lisinopril) or angiotensin receptor …
2. However, it is unclear whether ACE1 inhibitors (eg, lisinopril) or angiotensin receptor …
Coronavirus disease 2019 and hypertension: the role of angiotensin-converting enzyme 2 and the renin-angiotensin system
Hypertension emerged from early reports as a potential risk factor for worse outcomes for
persons with coronavirus disease 2019 (COVID-19). Among the putative links between …
persons with coronavirus disease 2019 (COVID-19). Among the putative links between …
Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19
MA Pedrosa, R Valenzuela, P Garrido-Gil… - Clinical …, 2021 - portlandpress.com
The key link between renin–angiotensin system (RAS) and COVID-19 is ACE2 (angiotensin-
converting enzyme 2), which acts as a double-edged sword, because ACE2 increases the …
converting enzyme 2), which acts as a double-edged sword, because ACE2 increases the …
[HTML][HTML] The renin–angiotensin system–a therapeutic target in COVID-19?
BRH Sturrock, KM Milne, TJT Chevassut - Clinical Medicine, 2020 - Elsevier
ABSTRACT COVID-19, caused by infection with SARS-CoV-2, is a disease characterised by
cough, fever and fatigue, which progresses to life-threatening lung injury in approximately …
cough, fever and fatigue, which progresses to life-threatening lung injury in approximately …
Renin-angiotensin system at the interface of COVID-19 infection
Abstract Angiotensin-converting enzyme 2 (ACE2) has been recognized as a potential entry
receptor for SARS-CoV-2 infection. Binding of SARS-CoV-2 to ACE2 allows engagement …
receptor for SARS-CoV-2 infection. Binding of SARS-CoV-2 to ACE2 allows engagement …
Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease
S Tsukamoto, H Wakui, K Azushima, T Yamaji… - Scientific Reports, 2021 - nature.com
Elevated angiotensin-converting enzyme 2 (ACE2) expression in organs that are potential
targets of severe acute respiratory syndrome coronavirus 2 may increase the risk of …
targets of severe acute respiratory syndrome coronavirus 2 may increase the risk of …
Potential differential effects of renin-angiotensin system inhibitors on SARS-CoV-2 infection and lung injury in COVID-19
M Furuhashi, N Moniwa, H Takizawa, N Ura… - Hypertension …, 2020 - nature.com
Since the beginning of the twenty-first century, epidemic outbreaks of deadly pneumonia
have been caused by three coronaviruses: severe acute respiratory syndrome (SARS) …
have been caused by three coronaviruses: severe acute respiratory syndrome (SARS) …