Over the last decade, metronomic chemotherapy has been increasingly considered as an
attractive strategy for treating cancer in a variety of settings. Beside pharmaco-economic …

Purpose Over the past few years, more and more new selective molecules directed against
specific cellular targets have become available for cancer therapy, leading to impressive …

Tumor angiogenesis is recognized as a major therapeutic target in the fight against cancer.
The key involvement of angiogenesis in tumor growth and metastasis has started to redefine …

Abstract Background A phase Ia/Ib trial of metronomic oral vinorelbine (MOV) driven by a
mathematical model was performed in heavily pretreated metastatic Non-Small Cell Lung …

Metronomic administration of chemotherapy has long been recognized as having a different
biological effect from maximal tolerated dose (MTD) administration. Preclinical studies have …

Metronomic chemotherapy describes the close, regular administration of chemotherapy
drugs at less-toxic doses over prolonged periods of time. In 2015, the results of randomized …

Metronomic chemotherapy is usually associated with better tolerance than conventional
chemotherapy, and encouraging response rates have been reported in various settings …

Results Overall, 13 patients were screened and 12 were treated (50% male, median age:
68yrs), including 9 NSCLC patients. All patients received at least one week (3 doses) of …

Background Metronomic oral vinorelbine is effective in metastatic NSCLC and malignant
pleural mesothelioma, but all the studies published thus far were based upon a variety of …

Abstract The Fourth Metronomic and Anti-angiogenic Therapy Meeting was held in Milan 24–
25 June 2014. The meeting was a true translational meeting where researchers and …