[HTML][HTML] Phillygenin attenuates inflammatory responses and influences glucose metabolic parameters by inhibiting Akt activity

W Liu, G Chu, N Chang, X Ma, M Jiang, G Bai - Rsc Advances, 2017 - pubs.rsc.org
Phillygenin (Phi) is one of the main chemical constituents of the fruit of Forsythia suspensa
(Thunb.) Vahl. It has various bioactivities, including anti-inflammatory, anti-obesity and …

Phillyrin alleviates high glucose-induced oxidative stress and inflammation in HBZY-1 cells through inhibition of the PI3K/Akt signaling pathway

C Yang, L Bao, Z Shi, X Xv, D Jiang… - Journal of Pharmacy …, 2024 - academic.oup.com
Background Phillyrin, the major lignin compound of Forsythia suspense (Thunb.) Vahl, has
been shown the effects of anti-inflammatory and antioxidant. Our study was aimed to explore …

[HTML][HTML] Insightful valorization of the biological activities of pani heloch leaves through experimental and computer-aided mechanisms

N Banu, N Alam, M Nazmul Islam, S Islam, SA Sakib… - Molecules, 2020 - mdpi.com
Pani heloch (Antidesma montanum) is traditionally used to treat innumerable diseases and
is a source of wild vegetables for the management of different pathological conditions. The …

[HTML][HTML] Stilbenoids from fenugreek seeds alleviate insulin resistance by regulating the PI3K/AKT/mTOR signaling pathway in a type 2 diabetes zebrafish model

Y Gao, Y Wu, F Tie, H Wang - Heliyon, 2024 - cell.com
Insulin resistance (IR) is the main cause of type 2 diabetes mellitus (T2DM). The specific
targets and underlying mechanisms responsible for the ameliorative effects of the stilbenoid …

[HTML][HTML] A comprehensive review on pharmacological, toxicity, and pharmacokinetic properties of phillygenin: Current landscape and future perspectives

C Wang, R Wu, S Zhang, L Gong, K Fu, C Yao… - Biomedicine & …, 2023 - Elsevier
Forsythiae Fructus is a traditional Chinese medicine frequently in clinics. It is extensive in the
treatment of various inflammation-related diseases and is renowned as' the holy medicine of …

Phillygenin inhibited LPS-induced RAW 264.7 cell inflammation by NF-κB pathway

M Zhou, Y Tang, L Liao, M Liu, Y Deng, X Zhao… - European Journal of …, 2021 - Elsevier
Inflammation is a common pathological phenomenon when homeostasis is seriously
disturbed. Phillygenin (PHI), a lignin component isolated from Forsythiae Fructus, has shown …

[HTML][HTML] Exploring the Underlying Mechanism of Alpinia officinarum Hance Ameliorating Diabetic Gastroparesis through Combining Network Pharmacology, Molecular …

X Zheng, Y Zhang, J Xu, X Li, H Wen… - Frontiers in Bioscience …, 2023 - imrpress.com
Background: Alpinia officinarum Hance (AOH) has a long history in China as a Chinese
medicine and exerts the pharmacological effects of antidiabetic and gastrointestinal …

In silico molecular interaction analysis and pharmacokinetic profiling of flavonoids from Catharanthus roseus (flower) against TXNIP protein

RRNS Pushpa, KS Babulal, R Kumaran, G Shoba… - Trends in …, 2023 - tis.wu.ac.th
Catharanthus roseus is a flowering plant whose flowers have been used in traditional
medicine to treat diabetes mellitus. Some of the flavonoids present in these flowers, namely …

[HTML][HTML] Decrypting molecular mechanism insight of Phyllanthus emblica L. fruit in the treatment of type 2 diabetes mellitus by network pharmacology

HU Chowdhury, M Adnan, KK Oh, DH Cho - Phytomedicine Plus, 2021 - Elsevier
Background Phyllanthus emblica L. fruits (PEf) are thought to be a good source of natural
antidiabetic compounds. Nevertheless, the bioactive ingredients and molecular mechanisms …

Antioxidant and Enzyme Inhibitory Activities of Rhoifolin Flavonoid: In Vitro and in Silico Studies

G Zengin, NM Mostafa, YM Abdelkhalek… - Chemistry & …, 2023 - Wiley Online Library
Abstract Rhoifolin (apigenin‐7‐O‐β‐neohesperidoside) belongs to the class of flavonoids
and was reported to exhibit anti‐inflammatory, cytotoxic, antidiabetic, hepatoprotective, and …