The aging process results in multiple traceable footprints, which can be quantified and used to estimate an organism's age. Examples of such aging biomarkers include epigenetic …
K Declerck, WV Berghe - Mechanisms of ageing and development, 2018 - Elsevier
Aging is the most important risk factor for major human lifestyle diseases, including cancer, neurological and cardiometabolic disorders. Due to the complex interplay between genetics …
Advanced age is the main common risk factor for cancer, cardiovascular disease and neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …
R Duan, Q Fu, Y Sun, Q Li - Ageing Research Reviews, 2022 - Elsevier
As a complicated process, aging is characterized by various changes at the cellular, subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age- related diseases and increase healthspan have suggested targeting the ageing process …
FH Xiao, HT Wang, QP Kong - Frontiers in genetics, 2019 - frontiersin.org
The biological markers of aging used to predict physical health status in older people are of great interest. Telomere shortening, which occurs during the process of cell replication, was …
Epigenetic alterations are a hallmark of aging and age‐related diseases. Computational models using DNA methylation data can create “epigenetic clocks” which are proposed to …
L Vidal-Bralo, Y Lopez-Golan, A Gonzalez - Frontiers in genetics, 2016 - frontiersin.org
Biological age is not always concordant with chronological age and the departures are of interest for understanding how diseases and environmental insults affect tissue function …
ME Levine - The Journals of Gerontology: Series A, 2020 - academic.oup.com
The Geoscience paradigm suggests that targeting the aging process could delay or prevent the risk of multiple major age-related diseases, such as cancer, cardiovascular disease …