Antibacterial and immunomodulatory activities of insect defensins-DLP2 and DLP4 against multidrug-resistant Staphylococcus aureus

Z Li, R Mao, D Teng, Y Hao, H Chen, X Wang… - Scientific reports, 2017 - nature.com
Methicillin-resistant Staphylococcus aureus (MRSA), are the most frequent cause of sepsis,
which urgently demanding new drugs for treating infection. Two homologous insect CSαβ …

An Enhanced Variant Designed From DLP4 Cationic Peptide Against Staphylococcus aureus CVCC 546

B Li, N Yang, X Wang, Y Hao, R Mao, Z Li… - Frontiers in …, 2020 - frontiersin.org
Insect defensins are promising candidates for the development of potent antimicrobials
against antibiotic-resistant Staphylococcus aureus (S. aureus). An insect defensin, DLP4 …

Defensin‐like peptide3 from black solder fly: Identification, characterization, and key amino acids for anti‐Gram‐negative bacteria

SI Park, SM Yoe - Entomological research, 2017 - Wiley Online Library
An antibacterial peptide was isolated from a black soldier fly, Hermetia illucens. The
molecular mass of this peptide was established as 4247.37 by matrix‐assisted laser …

In vitro and in vivo activity of antimicrobial peptides synthesized based on the insect defensin

H Saido-Sakanaka, J Ishibashi, E Momotani, F Amano… - Peptides, 2004 - Elsevier
Synthetic antimicrobial 9-mer peptides were designed from the amino acid sequence of an
active site of insect defensin to increase the number of positively charged amino acid …

A novel peptide antibiotic, Pro10-1D, designed from insect defensin shows antibacterial and anti-inflammatory activities in sepsis models

M Krishnan, J Choi, A Jang, Y Kim - International journal of molecular …, 2020 - mdpi.com
Owing to the challenges faced by conventional therapeutics, novel peptide antibiotics
against multidrug-resistant (MDR) gram-negative bacteria need to be urgently developed …

Purification and characterization of a novel antibacterial peptide from black soldier fly (Hermetia illucens) larvae

SI Park, JW Kim, SM Yoe - Developmental & Comparative Immunology, 2015 - Elsevier
In this study, we induced and purified a novel antimicrobial peptide exhibiting activity against
Gram-positive bacteria from the immunized hemolymph of Hermetia illucens larvae. The …

A recombinant fungal defensin-like peptide-P2 combats multidrug-resistant Staphylococcus aureus and biofilms

N Yang, D Teng, R Mao, Y Hao, X Wang… - Applied microbiology …, 2019 - Springer
There is an urgent need to discover new active drugs to combat methicillin-resistant
Staphylococcus aureus, which is a serious threat to humans and animals and incompletely …

Characterization of Cimex lectularius (bedbug) defensin peptide and its antimicrobial activity against human skin microflora

A Kaushal, K Gupta, ML van Hoek - Biochemical and biophysical research …, 2016 - Elsevier
Antimicrobial peptides are components of both vertebrate and invertebrate innate immune
systems that are expressed in response to exposure to bacterial antigens. Naturally …

Synthesis and characterization of bactericidal oligopeptides designed on the basis of an insect anti-bacterial peptide

H Saido-Sakanaka, J ISHIBASHI… - Biochemical …, 1999 - portlandpress.com
Defensin from a beetle, Allomyrina dichotoma, is known to have anti-bacterial activity
against Gram-positive bacteria. This peptide, which comprises 43 amino acid residues, was …

Molecular characterization and expression of the antimicrobial peptide defensin from the housefly (Musca domestica)

JX Wang, XF Zhao, YL Liang, L Li, W Zhang… - Cellular and Molecular …, 2006 - Springer
A 430-bp cDNA encoding the insect antimicrobial peptide defensin was cloned from the
housefly, and designated Musca domestica defensin (Mdde). The open reading frame of the …