Mucosal vaccines, sterilizing immunity, and the future of SARS-CoV-2 virulence

D Focosi, F Maggi, A Casadevall - Viruses, 2022 - mdpi.com
Sterilizing immunity after vaccination is desirable to prevent the spread of infection from
vaccinees, which can be especially dangerous in hospital settings while managing frail …

[HTML][HTML] Mucosal COVID-19 vaccines: Risks, benefits and control of the pandemic

D Miteva, M Peshevska-Sekulovska… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Based on mucosal immunization to promote both mucosal and systemic immune responses,
next-generation coronavirus disease 2019 (COVID-19) vaccines would be administered …

[HTML][HTML] Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines

V Mouro, A Fischer - Mucosal immunology, 2022 - Elsevier
The development and deployment of vaccines against COVID-19 demonstrated major
successes in providing immunity and preventing severe disease and death. Yet SARS-CoV …

Mucosal vaccines for SARS-CoV-2: scientific gaps and opportunities—workshop report

JM Knisely, LE Buyon, R Mandt, R Farkas… - npj Vaccines, 2023 - nature.com
On November 7th and 8th, 2022, The National Institute of Allergy and Infectious Diseases
(NIAID), part of the National Institutes of Health (NIH), The Coalition for Epidemic …

Development of SARS-CoV-2 vaccines: should we focus on mucosal immunity?

L Moreno-Fierros, I García-Silva… - Expert Opinion on …, 2020 - Taylor & Francis
The COVID-19 pandemic caused by the SARS-CoV-2 virus is having an unprecedented
impact on global health derived from its quick spread, which is attributed to its high stability …

Prevention of host-to-host transmission by SARS-CoV-2 vaccines

D Mostaghimi, CN Valdez, HT Larson… - The Lancet infectious …, 2022 - thelancet.com
As the number of individuals vaccinated against SARS-CoV-2 rises worldwide, population-
level data regarding the vaccines' ability to reduce infection are being generated …

Mucosal immunity: The missing link in comprehending SARS-CoV-2 infection and transmission

MW Russell, J Mestecky - Frontiers in immunology, 2022 - frontiersin.org
SARS-CoV-2 is primarily an airborne infection of the upper respiratory tract, which on
reaching the lungs causes the severe acute respiratory disease, COVID-19. Its first contact …

Mucosal vaccines for SARS-CoV-2: triumph of hope over experience

D Pilapitiya, AK Wheatley, HX Tan - EBioMedicine, 2023 - thelancet.com
Currently approved COVID-19 vaccines administered parenterally induce robust systemic
humoral and cellular responses. While highly effective against severe disease, there is …

COVID‐19 vaccinations: the unknowns, challenges, and hopes

K Mohamed, P Rzymski, MS Islam… - Journal of medical …, 2022 - Wiley Online Library
The entire world has been suffering from the coronavirus disease 2019 (COVID‐19)
pandemic since March 11, 2020. More than a year later, the COVID‐19 vaccination brought …

[HTML][HTML] Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques

Y Sui, J Li, R Zhang, SK Prabhu, H Andersen… - JCI insight, 2021 - ncbi.nlm.nih.gov
Effective SARS-CoV-2 vaccines are urgently needed. Although most vaccine strategies have
focused on systemic immunization, here we compared the protective efficacy of 2 …