Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations

LG de Almeida Chuffa, PP Freire… - Journal of Molecular …, 2022 - Springer
The risk of severe COVID-19 increases with age as older patients are at highest risk. Thus,
there is an urgent need to identify how severe acute respiratory syndrome coronavirus 2 …

The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2

RD Chow, M Majety, S Chen - Nature Communications, 2021 - nature.com
Age is a major risk factor for severe coronavirus disease-2019 (COVID-19). Here, we
interrogate the transcriptional features and cellular landscape of the aging human lung. By …

Single-cell transcriptomic atlas of primate cardiopulmonary aging

S Ma, S Sun, J Li, Y Fan, J Qu, L Sun, S Wang, Y Zhang… - Cell research, 2021 - nature.com
Aging is a major risk factor for many diseases, especially in highly prevalent
cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease …

Blood leukocyte transcriptional modules and differentially expressed genes associated with disease severity and age in COVID-19 patients

SY Bando, FB Bertonha, SE Vieira, DBL de Oliveira… - Scientific Reports, 2023 - nature.com
Since the molecular mechanisms determining COVID-19 severity are not yet well
understood, there is a demand for biomarkers derived from comparative transcriptome …

Biomarkers and immune repertoire metrics identified by peripheral blood transcriptomic sequencing reveal the pathogenesis of COVID-19

Y Liu, Y Wu, B Liu, Y Zhang, D San, Y Chen… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection is a global crisis; however, our current …

Weighted gene co-expression network analysis revealed T cell differentiation associated with the age-related phenotypes in COVID-19 patients

Y Lin, Y Li, H Chen, J Meng, J Li, J Chu, R Zheng… - BMC Medical …, 2023 - Springer
The risk of severe condition caused by Corona Virus Disease 2019 (COVID-19) increases
with age. However, the underlying mechanisms have not been clearly understood. The …

Blood transcriptome responses in patients correlate with severity of COVID-19 disease

Y Wang, K Schughart, TM Pelaia, T Chew… - Frontiers in …, 2023 - frontiersin.org
Background Coronavirus disease 2019 (COVID-19) is an infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Infected individuals …

A human circulating immune cell landscape in aging and COVID-19

Y Zheng, X Liu, W Le, L Xie, H Li, W Wen, S Wang… - Protein & …, 2020 - academic.oup.com
Age-associated changes in immune cells have been linked to an increased risk for infection.
However, a global and detailed characterization of the changes that human circulating …

High-density blood transcriptomics reveals precision immune signatures of SARS-CoV-2 infection in hospitalized individuals

JW Prokop, NL Hartog, D Chesla, W Faber… - Frontiers in …, 2021 - frontiersin.org
The immune response to COVID-19 infection is variable. How COVID-19 influences clinical
outcomes in hospitalized patients needs to be understood through readily obtainable …

Identification of PBMC-based molecular signature associational with COVID-19 disease severity

H Shaath, NM Alajez - Heliyon, 2021 - cell.com
The longevity of COVID-19 as a global pandemic, and the devastating effects it has had on
certain subsets of individuals thus far has highlighted the importance of identifying blood …