ACE2 and a Traditional Chinese Medicine Formula NRICM101 Could Alleviate the Inflammation and Pathogenic Process of Acute Lung Injury

CH Lin, YJ Chen, MW Lin, HJ Chang, XR Yang, CS Lin - Medicina, 2023 - mdpi.com
COVID-19 is a highly transmittable respiratory illness caused by SARS-CoV-2, and acute
lung injury (ALI) is the major complication of COVID-19. The challenge in studying SARS …

Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human ACE2-transgenic mice

Z Bi, W Hong, H Que, C He, W Ren, J Yang… - … and Targeted Therapy, 2021 - nature.com
The development of animal models for COVID-19 is essential for basic research and
drug/vaccine screening. Previously reported COVID-19 animal models need to be …

A novel hACE2 knock-in mouse model recapitulates pulmonary and intestinal SARS-CoV-2 infection

X Zhou, W Sun, Y Zhang, H Gu, R Wang, P Xie… - Frontiers in …, 2023 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission is
responsible for the coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV-2 uses the …

NRICM101 ameliorates SARS-CoV-2–S1-induced pulmonary injury in K18-hACE2 mice model

WC Wei, KC Tsai, CC Liaw, CT Chiou… - Frontiers in …, 2023 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic continues to represent a challenge for
public health globally since transmission of different variants of the virus does not seem to …

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF-and IFNγ-driven immunopathology

R Gawish, P Starkl, L Pimenov, A Hladik, K Lakovits… - Elife, 2022 - elifesciences.org
Despite tremendous progress in the understanding of COVID-19, mechanistic insight into
immunological, disease-driving factors remains limited. We generated maVie16, a mouse …

The K18-human ACE2 transgenic mouse model recapitulates non-severe and severe COVID-19 in response to an infectious dose of the SARS-CoV-2 virus

W Dong, H Mead, L Tian, JG Park, JI Garcia… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT A comprehensive analysis and characterization of a severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe …

[HTML][HTML] Severe acute respiratory syndrome coronavirus 2 ORF3a induces the expression of ACE2 in oral and pulmonary epithelial cells and the food supplement Vita …

A Aguilar-Lemarroy… - Experimental …, 2021 - … .spandidos-publications.com
Abstract The coronavirus disease 2019 (COVID‑19) pandemic has become a serious global
health problem and numerous studies are currently being conducted to improve …

Generation and characterization of a humanized ACE2 mouse model to study long‐term impacts of SARS‐CoV‐2 infection

CY Choi, K Gadhave, J Villano… - Journal of Medical …, 2024 - Wiley Online Library
Although the COVID‐19 pandemic has officially ended, the persistent challenge of long‐
COVID or post‐acute COVID sequelae (PASC) continues to impact societies globally …

Ace2 and innate immunity in the regulation of SARS-CoV-2-induced acute lung injury: A review

L Qu, C Chen, T Yin, Q Fang, Z Hong, R Zhou… - International journal of …, 2021 - mdpi.com
Despite the protracted battle against coronavirus acute respiratory infection (COVID-19) and
the rapid evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function

ES Winkler, AL Bailey, NM Kafai, S Nair, BT McCune… - BioRxiv, 2020 - biorxiv.org
ABSTRACT Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) emerged in
late 2019 and has spread worldwide resulting in the Coronavirus Disease 2019 (COVID-19) …