The prevailing hypothesis on the mechanism of radiation-induced cell killing identifies the
genetic material deoxyribonucleic acid (DNA) as the most important subcellular target at …

Understanding the critical lesions induced by ionizing radiation in DNA and their
relationship to cellular effects is an important challenge in radiation biology. Much evidence …

The role of the initial DNA double-strand breaks (dsb) as a determinant of cellular
radiosensitivity was studied in human breast and bladder cancer cell lines. Cell survival was …

Measurement of the surviving fraction after 2 Gy (SF 2) may predict for local control of the
tumour and patients cure, but clonogenic assays are unsuitable for wider clinical application …

A large number of reports suggest that DNA double-strand breaks (DSB) play a major role in
the radiation-induced killing of mammalian cells. However, the arguments supporting the …

The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of
lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double …

Ionizing radiation produces many types of DNA lesions that have the potential of killing cells.
The lethal lesion is probably an unrepaired or misrepaired double-strand break produced as …

Publisher Summary Although the direct relationship between DNA double-strand breaks
and cell survival has not yet been established experimentally in eukaryotic cells, this chapter …

TN-368 lepidopteran insect cells are on the order of 100 times more resistant to the lethal
effects of ionizing radiation than cultured mammalian cells. DNA double-strand breaks …

The successful use of radiation to treat cancer results primarily from its ability to cause the
death of individual tumour cells. The biological consequences of irradiation, including cell …