Retinoic acid (RA) induces the neuronal differentiation of many human neuroblastoma cell
lines. In this study, we show that RA treatment of neuroblastoma cells induces the …

Retinoic acid (RA) induces the differentiation of many cell lines, including those derived from
neuroblastoma. RA treatment of SH‐SY5Y cells induces the appearance of functional Trk B …

Expression of full-length trkB can be found in some highly malignant neuroblastoma tumors
with an amplified MYCN gene. This contrasts sympathetic neuroblasts, from which …

A large number of poor prognosis neuroblastoma (NB) tumors constitutively express brain-
derived neurotrophic factor (BDNF) and variably express the gene for its tyrosine kinase …

There is considerable interest in the role of the TRK family of neuotrophin receptors in
regulating growth and differentiation in normal and neoplastic nerve cells. A neuroblastoma …

Regulation of Trk receptors by their ligands, the neurotrophins, was investigated in
dissociated cultures of embryonic day 18 rat hippocampal neurons. Cultures were exposed …

Chronic exposure of brain neurons to nerve growth factor in vitro and in vivo results in
increased levels of the nerve growth factor receptor TrkA. In contrast, in the present study …

Activation of the neurotrophin receptor TrkA by its ligand nerve growth factor (NGF) initiates
a cascade of signaling events leading to neuronal differentiation in vitro and might play an …

By northern blot analysis and ribonuclease protection assay, we observed the presence of a
high level of trkB mRNA in primary brain cultures devoid of neuronal cells and highly …

During development of the mammalian cerebral cortex neural stem cells (NSC) first
generate neurons and subsequently produce glial cells. The mechanism (s) responsible for …