Novel methods for multi-ancestry polygenic prediction and their evaluations in 5.1 million individuals of diverse ancestry
Polygenic risk scores are becoming increasingly predictive of complex traits, but their
suboptimal performance in non-European ancestry populations raises questions about their …
suboptimal performance in non-European ancestry populations raises questions about their …
A new method for multiancestry polygenic prediction improves performance across diverse populations
Polygenic risk scores (PRSs) increasingly predict complex traits; however, suboptimal
performance in non-European populations raise concerns about clinical applications and …
performance in non-European populations raise concerns about clinical applications and …
An ensemble penalized regression method for multi-ancestry polygenic risk prediction
Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve
the prediction of complex traits and diseases. However, most existing PRS are primarily …
the prediction of complex traits and diseases. However, most existing PRS are primarily …
Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics
Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of
Europeans are known to have substantially reduced predictive accuracy in non-European …
Europeans are known to have substantially reduced predictive accuracy in non-European …
Improving polygenic prediction in ancestrally diverse populations
Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As
existing genome-wide association studies (GWAS) have been conducted predominantly in …
existing genome-wide association studies (GWAS) have been conducted predominantly in …
BridgePRS: A powerful trans-ancestry Polygenic Risk Score method
Abstract Polygenic Risk Scores (PRS) have huge potential to contribute to biomedical
research and to a future of precision medicine, but to date their calculation relies largely on …
research and to a future of precision medicine, but to date their calculation relies largely on …
Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI
Q Sun, BT Rowland, J Chen, AV Mikhaylova… - Nature …, 2024 - nature.com
Polygenic risk scores (PRS) have shown successes in clinics, but most PRS methods focus
only on participants with distinct primary continental ancestry without accommodating …
only on participants with distinct primary continental ancestry without accommodating …
Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-specific effects via GAUDI
Polygenic risk scores (PRS) have shown successes in clinics, but most PRS methods have
focused only on individuals with one primary continental ancestry, thus poorly …
focused only on individuals with one primary continental ancestry, thus poorly …
The construction of multi-ethnic polygenic risk score using transfer learning
As most existing genome-wide association studies (GWAS) were conducted in European
ancestry cohorts and as the existing PRS models have limited transferability across ancestry …
ancestry cohorts and as the existing PRS models have limited transferability across ancestry …
[PDF][PDF] A unified framework for cross-population trait prediction by leveraging the genetic correlation of polygenic traits
The development of polygenic risk scores (PRSs) has proved useful to stratify the general
European population into different risk groups. However, PRSs are less accurate in non …
European population into different risk groups. However, PRSs are less accurate in non …