Nephrotic syndrome (NS) is divided into steroid-sensitive (SSNS) and-resistant (SRNS)
variants. SRNS causes end-stage kidney disease, which cannot be cured. While the disease …

Background Congenital nephrotic syndrome arises from a defect in the glomerular filtration
barrier that permits the unrestricted passage of protein across the barrier, resulting in …

The specialized epithelial cell of the kidney, the podocyte, has a complex actin-based
cytoskeleton. Dynamic regulation of this cytoskeleton is required for efficient barrier function …

Background Over the last decade, advances in genetic techniques have resulted in the
identification of rare hereditary disorders of renal magnesium and salt handling …

Background Steroid-resistant nephrotic syndrome (SRNS) is a frequent cause of CKD. The
discovery of monogenic causes of SRNS has revealed specific pathogenetic pathways, but …

Blockade of mineralocorticoid receptor has been shown to improve the clinical outcomes of
proteinuric kidney diseases,. However, little is known about the regulation of …

Hypertension is a leading contributor to cardiovascular mortality worldwide. Despite this, its
underlying mechanism (s) and the role of excess salt in cardiorenal dysfunction are unclear …

Identification of single-gene causes of steroid-resistant nephrotic syndrome (SRNS) has
furthered the understanding of the pathogenesis of this disease. Here, using a combination …

The progression of diabetic kidney disease (DKD), a leading cause of end-stage kidney
disease, involves mineralocorticoid receptor (MR) activation. We previously identified …

No efficient treatment exists for nephrotic syndrome (NS), a frequent cause of chronic kidney
disease. Here we show mutations in six different genes (MAGI2, TNS2, DLC1, CDK20 …