Molecular mechanisms of long noncoding RNAs

KC Wang, HY Chang - Molecular cell, 2011 - cell.com
Long noncoding RNAs (lncRNAs) are an important class of pervasive genes involved in a
variety of biological functions. Here we discuss the emerging archetypes of molecular …

Long noncoding RNAs: past, present, and future

JTY Kung, D Colognori, JT Lee - Genetics, 2013 - academic.oup.com
Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a
potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been …

Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs

VA Moran, RJ Perera, AM Khalil - Nucleic acids research, 2012 - academic.oup.com
The recent discovery that the human and other mammalian genomes produce thousands of
long non-coding RNAs (lncRNAs) raises many fascinating questions. These mRNA-like …

Unique features of long non-coding RNA biogenesis and function

JJ Quinn, HY Chang - Nature reviews genetics, 2016 - nature.com
Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous
biological processes across every branch of life. Although initially discovered as mRNA-like …

Technological developments in lncRNA biology

S Jathar, V Kumar, J Srivastava, V Tripathi - Long Non Coding RNA …, 2017 - Springer
It is estimated that more than 90% of the mammalian genome is transcribed as non-coding
RNAs. Recent evidences have established that these non-coding transcripts are not junk or …

The specificity of long noncoding RNA expression

BS Gloss, ME Dinger - Biochimica et Biophysica Acta (BBA)-Gene …, 2016 - Elsevier
Over the last decade, long noncoding RNAs (lncRNAs) have emerged as a fundamental
molecular class whose members play pivotal roles in the regulation of the genome. The …

Evolution and functions of long noncoding RNAs

CP Ponting, PL Oliver, W Reik - Cell, 2009 - cell.com
RNA is not only a messenger operating between DNA and protein. Transcription of
essentially the entire eukaryotic genome generates a myriad of non-protein-coding RNA …

Long noncoding RNAs: lincs between human health and disease

ZH Kwok, Y Tay - Biochemical Society Transactions, 2017 - portlandpress.com
Long noncoding RNAs (lncRNAs) represent one of the largest classes of transcripts and are
highly diverse in terms of characteristics and functions. Advances in high-throughput …

Long non-coding RNAs: definitions, functions, challenges and recommendations

JS Mattick, PP Amaral, P Carninci… - … reviews Molecular cell …, 2023 - nature.com
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts

S Geisler, J Coller - Nature reviews Molecular cell biology, 2013 - nature.com
The increased application of transcriptome-wide profiling approaches has led to an
explosion in the number of documented long non-coding RNAs (lncRNAs). While these new …