Duchenne muscular dystrophy (DMD) is the most prevalent and severe form of human
muscular dystrophy. While clinical descriptions of DMD date back to the 1850's, over 100 …

The absence of dystrophin in skeletal muscle is the underlying cause of Duchenne muscular
dystrophy (DMD), a severe form of muscle disease characterized by progressive muscle …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

Duchenne muscular dystrophy is the most prevalent and severe form of human muscular
dystrophy. Investigations into the molecular basis for Duchenne muscular dystrophy were …

The membrane cytoskeletal component dystrophin and its associated glycoproteins play a
central role in the molecular pathogenesis of several muscular dystrophies, ie …

The dystrophin-glycoprotein complex spans the sarcolemma to provide a linkage between
the subsarcolemmal cytoskeleton and the extracellular matrix in skeletal muscle. In …

Mutations in dystrophin lead to Duchenne muscular dystrophy, which is among the most
common human genetic disorders. Dystrophin nucleates assembly of the dystrophin …

Muscular dystrophies are a group of diseases that primarily affect skeletal muscle and are
characterized by progressive muscle wasting and weakness. Although these diseases have …

The almost complete loss of the membrane cytoskeletal protein dystrophin and concomitant
drastic reduction in dystrophin-associated glycoproteins are the underlying mechanisms of …

Dystrophin, the protein product of the DMD gene, is a component of the muscle-membrane
cytoskeleton. Mutations in the DMD gene result in the allelic myopathies Duchenne and …