[PDF][PDF] Prioritizing GWAS results: a review of statistical methods and recommendations for their application

RM Cantor, K Lange, JS Sinsheimer - The American Journal of Human …, 2010 - cell.com
Genome-wide association studies (GWAS) have rapidly become a standard method for
disease gene discovery. A substantial number of recent GWAS indicate that for most …

Benefits and limitations of genome-wide association studies

V Tam, N Patel, M Turcotte, Y Bossé, G Paré… - Nature Reviews …, 2019 - nature.com
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

Statistical methods for genome-wide association studies

MH Wang, HJ Cordell, K Van Steen - Seminars in cancer biology, 2019 - Elsevier
Genome-wide association studies (GWAS) detect common genetic variants associated with
complex disorders. With their comprehensive coverage of common single nucleotide …

[HTML][HTML] Guidelines for genome-wide association studies

GS Barsh, GP Copenhaver, G Gibson… - PLoS genetics, 2012 - journals.plos.org
Genome-wide association studies (GWAS) have revolutionized human genetics. They have
led to the identification of thousands of loci that affect both normal variation and susceptibility …

Genome-wide association studies: hypothesis-“free” or “engaged”?

GD Kitsios, E Zintzaras - Translational Research, 2009 - Elsevier
The advent of the first wave of genome-wide association studies (GWAS) provided a new
conceptual framework in the search for variants underlying common disorders: a massive …

Genome-wide association studies

A Dehghan - Genetic Epidemiology: Methods and Protocols, 2018 - Springer
Genetic association studies have made a major contribution to our understanding of the
genetics of complex disorders over the last 10 years through genome-wide association …

[HTML][HTML] Genome-wide association studies

E Uffelmann, QQ Huang, NS Munung… - Nature Reviews …, 2021 - nature.com
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …

How to interpret a genome-wide association study

TA Pearson, TA Manolio - Jama, 2008 - jamanetwork.com
Genome-wide association (GWA) studies use high-throughput genotyping technologies to
assay hundreds of thousands of single-nucleotide polymorphisms (SNPs) and relate them to …

[HTML][HTML] Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies

K Siontis, NA Patsopoulos, J Ioannidis - European Journal of Human …, 2010 - nature.com
Genome-wide association studies (GWASs) have created a paradigm shift in discovering
genetic associations for common diseases and phenotypes, but it is unclear whether the …

[HTML][HTML] An open access database of genome-wide association results

AD Johnson, CJ O'Donnell - BMC medical genetics, 2009 - Springer
Background The number of genome-wide association studies (GWAS) is growing rapidly
leading to the discovery and replication of many new disease loci. Combining results from …