Innate immunity in COVID-19 patients mediated by NKG2A receptors, and potential treatment using Monalizumab, Cholroquine, and antiviral agents
A Yaqinuddin, J Kashir - Medical hypotheses, 2020 - Elsevier
Following the outbreak of a novel coronavirus (SARS-CoV-2), studies suggest that the
resultant disease (COVID-19) is more severe in individuals with a weakened immune …
resultant disease (COVID-19) is more severe in individuals with a weakened immune …
NKG2A and COVID-19: another brick in the wall
L Antonioli, M Fornai, C Pellegrini… - Cellular & molecular …, 2020 - nature.com
Coronavirus disease 2019 (COVID-19) is a viral infection caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2; formerly designated as 2019-nCoV), a …
respiratory syndrome coronavirus 2 (SARS-CoV-2; formerly designated as 2019-nCoV), a …
[HTML][HTML] Cell-type-specific immune dysregulation in severely ill COVID-19 patients
Recent studies have demonstrated immunologic dysfunction in severely ill coronavirus
disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to …
disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to …
Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19
Our understanding of protective versus pathological immune responses to SARS-CoV-2, the
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …
SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D
Natural killer (NK) cells are cytotoxic effector cells that target and lyse virally infected cells;
many viruses therefore encode mechanisms to escape such NK cell killing. Here, we …
many viruses therefore encode mechanisms to escape such NK cell killing. Here, we …
SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies
CA Fielding, P Sabberwal, JC Williamson… - Elife, 2022 - elifesciences.org
The outcome of infection is dependent on the ability of viruses to manipulate the infected cell
to evade immunity, and the ability of the immune response to overcome this evasion …
to evade immunity, and the ability of the immune response to overcome this evasion …
Severe COVID-19 patients exhibit an ILC2 NKG2D+ population in their impaired ILC compartment
A Gomez-Cadena, L Spehner, M Kroemer… - Cellular & Molecular …, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the
current COVID-19 disease pandemic. In some patients, the symptoms are mild, and a …
current COVID-19 disease pandemic. In some patients, the symptoms are mild, and a …
SARS-CoV-2 spike 1 protein controls natural killer cell activation via the HLA-E/NKG2A pathway
Natural killer cells are important in the control of viral infections. However, the role of NK
cells during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has …
cells during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has …
Single-cell landscape of immunological responses in patients with COVID-19
Abstract In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity …
syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity …
Harnessing memory NK cell to protect against COVID-19
S Soleimanian, R Yaghobi - Frontiers in pharmacology, 2020 - frontiersin.org
The worldwide struggle against the coronavirus disease 2019 (COVID-19) as a public health
crisis continues to sweep across the globe. Up to now, effective antiviral treatment against …
crisis continues to sweep across the globe. Up to now, effective antiviral treatment against …