Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound NKT cell impairment

J Liu, X Yang, H Wang, Z Li, H Deng, J Liu, S Xiong… - MBio, 2021 - Am Soc Microbiol
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affected over 120 million people …

Elevated Exhaustion Levels of NK and CD8+ T Cells as Indicators for Progression and Prognosis of COVID-19 Disease

M Li, W Guo, Y Dong, X Wang, D Dai, X Liu… - Frontiers in …, 2020 - frontiersin.org
Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) induced
Coronavirus Disease 2019 (COVID-19) has posed a global threat to public health. The …

Immune response in severe and non-severe coronavirus disease 2019 (COVID-19) infection: a mechanistic landscape

K Mukund, P Nayak, C Ashokkumar, S Rao… - Frontiers in …, 2021 - frontiersin.org
The mechanisms underlying the immune remodeling and severity response in coronavirus
disease 2019 (COVID-19) are yet to be fully elucidated. Our comprehensive integrative …

Exhausted NK cells and cytokine storms in COVID-19: Whether NK cell therapy could be a therapeutic choice

M Ghasemzadeh, A Ghasemzadeh, E Hosseini - Human immunology, 2022 - Elsevier
The global outbreak of coronavirus-2019 (COVID-19) still claims more lives daily around the
world due to the lack of a definitive treatment and the rapid tendency of virus to mutate …

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

M Zheng, Y Gao, G Wang, G Song, S Liu… - Cellular & molecular …, 2020 - nature.com
In December 2019, a novel coronavirus was first reported in Wuhan, China. 1 It was named
by the World Health Organization as severe acute respiratory syndrome coronavirus 2 …

Unique immunological profile in patients with COVID-19

S Varchetta, D Mele, B Oliviero, S Mantovani… - Cellular & molecular …, 2021 - nature.com
The relationship between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
and host immunity is poorly understood. We performed an extensive analysis of immune …

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

D Mathew, JR Giles, AE Baxter, DA Oldridge… - Science, 2020 - science.org
INTRODUCTION Many patients with coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with …

Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression

AF Rendeiro, J Casano, CK Vorkas… - Life science …, 2021 - life-science-alliance.org
With a rising incidence of COVID-19–associated morbidity and mortality worldwide, it is
critical to elucidate the innate and adaptive immune responses that drive disease severity …

Comprehensive mapping of immune perturbations associated with severe COVID-19

L Kuri-Cervantes, MB Pampena, W Meng… - Science …, 2020 - science.org
Although critical illness has been associated with SARS-CoV-2–induced hyperinflammation,
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …

Innate lymphoid cell composition associates with COVID‐19 disease severity

M García, E Kokkinou… - Clinical & …, 2020 - Wiley Online Library
Objectives The role of innate lymphoid cells (ILCs) in coronavirus disease 2019 (COVID‐
19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is …