Heightened innate immune responses in the respiratory tract of COVID-19 patients
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2
infection have posed a severe threat to global public health. It is unclear how the human …
infection have posed a severe threat to global public health. It is unclear how the human …
Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates
MD Fahlberg, RV Blair, LA Doyle-Meyers… - Nature …, 2020 - nature.com
Understanding SARS-CoV-2 associated immune pathology is crucial to develop pan-
effective vaccines and treatments. Here we investigate the immune events from the acute …
effective vaccines and treatments. Here we investigate the immune events from the acute …
Tocilizumab treatment in severe COVID-19 patients attenuates the inflammatory storm incited by monocyte centric immune interactions revealed by single-cell …
ABSTRACT Coronavirus disease 2019 (COVID-19) has caused more than 40,000 deaths
worldwide. Approximately 14% of patients with COVID-19 experienced severe disease and …
worldwide. Approximately 14% of patients with COVID-19 experienced severe disease and …
SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells
N Huot, C Planchais, P Rosenbaum, V Contreras… - Nature …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA generally becomes
undetectable in upper airways after a few days or weeks postinfection. Here we used a …
undetectable in upper airways after a few days or weeks postinfection. Here we used a …
Overly exuberant innate immune response to SARS-CoV-2 infection
Z Zhou, L Ren, LI Zhang, J Zhong, Y Xiao, Z Jia, L Guo… - 2020 - papers.ssrn.com
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2
infection has posed a severe threat to global public health. It is unclear how the human …
infection has posed a severe threat to global public health. It is unclear how the human …
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection
Coordinated local mucosal and systemic immune responses following severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection either protect against …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection either protect against …
Single-cell multi-omics analysis of the immune response in COVID-19
Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity
R Edahiro, Y Shirai, Y Takeshima, S Sakakibara… - Nature …, 2023 - nature.com
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory
syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T …
syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T …
[HTML][HTML] Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19
COVID-19 exhibits extensive patient-to-patient heterogeneity. To link immune response
variation to disease severity and outcome over time, we longitudinally assessed circulating …
variation to disease severity and outcome over time, we longitudinally assessed circulating …
[HTML][HTML] A functionally distinct neutrophil landscape in severe COVID-19 reveals opportunities for adjunctive therapies
Acute respiratory distress syndrome (ARDS) is a life-threatening syndrome, constituted by
respiratory failure and diffuse alveolar damage that results from dysregulated local and …
respiratory failure and diffuse alveolar damage that results from dysregulated local and …