Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals

MM Steger, C Maczek… - Clinical & …, 1996 - Wiley Online Library
Dendritic cells are antigen‐presenting cells (APC), which are crucial for the initiation of an
immune response. In spite of the well known decline of immune function in old age, no …

Peripheral blood dendritic cells reinduce proliferation in in vitro aged T cell populations

MM Steger, C Maczek… - Mechanisms of ageing and …, 1997 - Elsevier
Dendritic cells (DC) are professional antigen presenting cells which are essential for the
initiation of an immune response. Recently we demonstrated that DC, which had been …

Peripheral blood dendritic cells and monocytes are differently regulated in the elderly

S Della Bella, L Bierti, P Presicce, R Arienti, M Valenti… - Clinical …, 2007 - Elsevier
Dendritic cells (DCs) are the single most central player in all immune responses. To assess
whether DC alterations may contribute to the immune dysregulation that affects the elderly …

Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells

TL Lung, M Saurwein-Teissl, W Parson, D Schönitzer… - Vaccine, 2000 - Elsevier
Dendritic cells (DC) are powerful antigen presenting cells, which have the unique capacity to
stimulate naive T cells. In spite of the well-known decline of T cell function in old age, little …

Dendritic cells in old age-neglected by gerontology?

M Saurwein-Teissl, N Romani… - Mechanisms of ageing …, 2001 - Elsevier
Dendritic cells (DC) are known as the most efficient antigen-presenting cell type to activate T
cells and are key modulators of the immune response. Due to their central role in …

Dendritic cells in human aging

A Agrawal, S Agrawal, S Gupta - Experimental gerontology, 2007 - Elsevier
Dendritic cells (DCs) play a critical role in linking innate and adaptive immunity. A role of
DCs in immunosenescence and chronic inflammation associated with aging has not been …

Surface markers and transendothelial migration of dendritic cells from elderly subjects

P Pietschmann, P Hahn, S Kudlacek, R Thomas… - Experimental …, 2000 - Elsevier
Age-related changes of immune functions have been extensively investigated in both
humans and animal models; nevertheless, the literature on potential alterations of dendritic …

Reduced numbers of plasmacytoid dendritic cells in aged blood donors

B Pérez-Cabezas, M Naranjo-Gómez… - Experimental …, 2007 - Elsevier
Dendritic cells (DC) play essential functions in both innate and adaptive immune responses.
Peripheral blood DCs are divided into two major subsets, named conventional DC (cDC) …

Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway

A Agrawal, S Agrawal, JN Cao, H Su… - The Journal of …, 2007 - journals.aai.org
Aging represents a state of paradox where chronic inflammation is associated with declining
immune responses. Dendritic cells (DCs) are the major APCs responsible for initiating an …

Circulating, interferon‐producing plasmacytoid dendritic cells decline during human ageing

M Shodell, FP Siegal - Scandinavian journal of immunology, 2002 - Wiley Online Library
Increased frequency and severity of infections in the elderly have been taken as indicative of
declining immune function. Dendritic cells (DCs), the most important antigen‐presenting …