Human lifespan has increased from a median of 46.5 years in 1950 to 71.7 years in 2022.
As people age, one of the inevitable consequences is a decline in kidney function and …

Background In elderly patients chronic kidney disease often limits drug prescription. As
several equations for quick assessment of kidney function by estimating glomerular filtration …

The aging process is characterized by relevant changes in pharmacokinetics. Renal function
is known to decline with aging. However, as a result of reduced muscle mass, older …

Adverse drug effects as a consequence of inappropriate dosage are a common cause of
hospitalization among the elderly. Older individuals are at a particular risk of overdosing …

Objectives To evaluate the performance of kidney function estimation equations and to
determine the frequency of drug dose discordance in an older population. Design Cross …

The study evaluated whether the renal function decline rate per year with age in adults
varies based on two primary statistical analyses: cross‐section (CS), using one observation …

Estimates of glomerular filtration rate (eGFR) should provide accurate measure of an
individual's kidney function because important clinical decisions such as timing of renal …

Background The risk of incorrect medication dosing is high in frail older people. Therefore,
accurate assessment of the glomerular filtration rate is important. Objective The objective of …

Purpose The elderly are at risk for adverse drug events because of inappropriate dosing of
renally eliminated medications. The purpose of this study was to evaluate differences in …

The most important clinical renal function to monitor with aging is the glomerular filtration
rate (creatinine clearance). Most decisions on drug dosage can be based on this information …