Combining Hepatic Percutaneous Perfusion with Ipilimumab plus Nivolumab in advanced uveal melanoma (CHOPIN): study protocol for a phase Ib/randomized …
TML Tong, MK van der Kooij, FM Speetjens… - Trials, 2022 - Springer
Background While immune checkpoint inhibition (ICI) has revolutionized the treatment of
metastatic cutaneous melanoma, no standard treatments are available for patients with …
metastatic cutaneous melanoma, no standard treatments are available for patients with …
Combining melphalan percutaneous hepatic perfusion with ipilimumab plus nivolumab in advanced uveal melanoma: first safety and efficacy data from the phase Ib …
TML Tong, MC Burgmans, FM Speetjens… - CardioVascular and …, 2023 - Springer
Purpose To define a safe treatment dose of ipilimumab (IPI) and nivolumab (NIVO) when
applied in combination with percutaneous hepatic perfusion with melphalan (M-PHP) in …
applied in combination with percutaneous hepatic perfusion with melphalan (M-PHP) in …
[HTML][HTML] A phase Ib randomized multicenter trial of isolated hepatic perfusion in combination with ipilimumab and nivolumab for uveal melanoma metastases …
RO Bagge, A Nelson, A Shafazand, C Cahlin… - ESMO open, 2024 - Elsevier
Background Uveal melanoma (UM) is a rare malignancy where 50% of patients develop
metastatic disease primarily affecting the liver. Approximately 40% of patients with metastatic …
metastatic disease primarily affecting the liver. Approximately 40% of patients with metastatic …
Combination of immune checkpoint inhibitors and liver-specific therapies in liver-metastatic uveal melanoma: can we thus overcome its high resistance?
CL Blomen, J Kött, TI Hartung, LK Torster, C Gebhardt - Cancers, 2021 - mdpi.com
Simple Summary Immune checkpoint inhibitors (ICI) have failed to overcome the high
therapy resistance of Metastatic Uveal Melanoma (MUM) in contrast to the dramatic benefits …
therapy resistance of Metastatic Uveal Melanoma (MUM) in contrast to the dramatic benefits …
Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a …
EAT Koch, A Petzold, A Wessely, E Dippel… - Frontiers of …, 2023 - Springer
Metastases of uveal melanoma (UM) spread predominantly to the liver. Due to low response
rates to systemic therapies, liver-directed therapies (LDT) are commonly used for tumor …
rates to systemic therapies, liver-directed therapies (LDT) are commonly used for tumor …
Safety and efficacy of ipilimumab plus nivolumab and sequential selective internal radiation therapy in hepatic and extrahepatic metastatic uveal melanoma
V Aedo-Lopez, CL Gérard, S Boughdad… - Cancers, 2022 - mdpi.com
Simple Summary Despite recent progress on the treatment of metastatic uveal melanoma
(mUM), prognosis remains dismal for the majority of patients. Directed liver therapies …
(mUM), prognosis remains dismal for the majority of patients. Directed liver therapies …
Poor response to checkpoint immunotherapy in uveal melanoma highlights the persistent need for innovative regional therapy approaches to manage liver …
BM Szeligo, AD Ivey, BA Boone - Cancers, 2021 - mdpi.com
Simple Summary Uveal melanoma is a cancer that develops from melanocytes in the eye.
This disease is extremely rare and has a strong predilection for liver metastasis, which has a …
This disease is extremely rare and has a strong predilection for liver metastasis, which has a …
Hepatic and overall progression-free survival after percutaneous hepatic perfusion (PHP) as first-line or second-line therapy for metastatic uveal melanoma
H Ghali, MM Dugan, S Aflatooni, A Boby… - Annals of Surgical …, 2024 - Springer
Background Uveal melanoma often metastasizes to the liver, portending a poor prognosis.
Melphalan/hepatic delivery system (HDS) via percutaneous hepatic perfusion (PHP) is a …
Melphalan/hepatic delivery system (HDS) via percutaneous hepatic perfusion (PHP) is a …
Percutaneous hepatic perfusion (PHP) with melphalan in liver-dominant metastatic uveal melanoma: the German experience
CLA Dewald, MM Warnke, R Brüning, MA Schneider… - Cancers, 2021 - mdpi.com
Simple Summary Percutaneous hepatic perfusion (PHP) with melphalan is an innovative
technique that facilitates the delivery of high-dose chemotherapy to hepatic tumors while …
technique that facilitates the delivery of high-dose chemotherapy to hepatic tumors while …
Hepatic radiotherapy in addition to anti-PD-1 for the treatment of metastatic uveal melanoma patients
E Rossi, F Cellini, MM Pagliara, MG Sammarco… - Cancers, 2023 - mdpi.com
Simple Summary Uveal melanoma often metastasizes to the liver. Immune checkpoint
inhibitors showed low efficacy in this disease. Liver directed therapies are widely employed …
inhibitors showed low efficacy in this disease. Liver directed therapies are widely employed …