Neurodegenerative disease is a disease state in which neurons in the spinal cord and brain
are lost. Studies show that sustained neuroinflammatory reactions release toxic factors …

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Although its
pathogenesis remains unclear, studies have indicated microglia-mediated …

Isorhamnetin, which is a flavonoid predominantly found in fruits and leaves of various plants,
including Hippophae rhamnoides L. and Oenanthe javanica (Blume) DC, is known to …

Neuroinflammation is a specific or nonspecific immunological reaction in the central nervous
system that is induced by microglia activation. Appropriate regulation of activated microglial …

Under normal conditions in the brain, microglia play roles in homeostasis regulation and
defense against injury. However, over-activated microglia secrete proinflammatory and …

The activation of microglia is decisively involved with the neurodegeneration observed in
many neuroinflammatory pathologies, such as multiple sclerosis, Parkinson's disease, and …

Neuroinflammation is one of the main mechanisms involved in the progression of
neurodegeneration. The activation of microglia is the main feature of neuroinflammation …

Microglial activation and the resulting neuroinflammation are associated with a variety of
brain diseases, such as Alzheimer's disease and Parkinson's disease. Thus, the control of …

In the present study, we investigated whether β-hydroxyisovalerylshikonin (β-HIVS) affects
the production of proinflammatory mediators such as nitric oxide (NO) and prostaglandin E 2 …

Inflammatory processes in the central nervous system are feature among biological
reactions to harmful stimuli such as pathogens and damaged cells. In resting conditions …