Acute lymphoblastic leukemia (ALL) is one of the most common forms of malignancy that
occurs in lymphoid progenitor cells, particularly in children. Synthetic steroid hormones …

Despite many evidences supporting the concept of “oncogene addiction” and many
hypotheses rationalizing it, there is still a lack of detailed understanding to the precise …

Glucocorticoids (GCs) are among the most widely prescribed medications in clinical
practice. The beneficial effects of GCs in acute lymphoblastic leukemia (ALL) are based on …

Background Molecular mechanisms of the functional alteration of hematopoietic stem cells
(HSCs) in leukemic environment attract intensive research interests. As known in previous …

Acute lymphoblastic leukaemia (ALL) is the most frequent childhood cancer and, although it
is highly treatable, resistance to therapy, toxicity and side effects remain challenging. The …

Background It has been shown previously that glucocorticoids exert a dual mechanism of
action, entailing cytotoxic, mitogenic as well as cell proliferative and anti-apoptotic …

The over-expression of the Bcl-2 protein is a common feature of many solid cancers and
hematological malignancies, and it is typically associated with poor prognosis and …

Glucocorticoids (GC) are the foundation of the chemotherapy regimen in acute
lymphoblastic leukemia (ALL). However, resistance to GC is observed more frequently than …

The ongoing cancer research has shown that malignant tumour cells have highly disrupted
signalling transduction pathways. In cancer cells, signalling pathways are altered to satisfy …

Gene expression is a combinatorial function of genetic/epigenetic factors such as copy
number variation (CNV), DNA methylation (DM), transcription factors (TF) occupancy, and …