Tumor angiogenesis—characteristics of tumor endothelial cells

K Hida, N Maishi, C Torii, Y Hida - International journal of clinical oncology, 2016 - Springer
Tumor blood vessels provide nutrition and oxygen to the tumor, resulting in tumor
progression. They also act as gatekeepers, inducing tumor metastasis. Thus, targeting tumor …

Contribution of tumor endothelial cells in cancer progression

K Hida, N Maishi, DA Annan, Y Hida - International journal of molecular …, 2018 - mdpi.com
Tumor progression depends on the process of angiogenesis, which is the formation of new
blood vessels. These newly formed blood vessels supply oxygen and nutrients to the tumor …

Heterogeneity of tumor endothelial cells

K Hida, N Ohga, K Akiyama, N Maishi, Y Hida - Cancer science, 2013 - Wiley Online Library
Tumor blood vessels play important roles in tumor progression and metastasis. Thus,
targeting tumor blood vessels is an important strategy for cancer therapy. Tumor endothelial …

Tumor endothelial heterogeneity in cancer progression

N Maishi, DA Annan, H Kikuchi, Y Hida, K Hida - Cancers, 2019 - mdpi.com
Tumor blood vessels supply nutrients and oxygen to tumor cells for their growth and provide
routes for them to enter circulation. Thus, angiogenesis, the formation of new blood vessels …

Characterization of molecular and functional alterations of tumor endothelial cells to design anti-angiogenic strategies

B Bussolati, MC Deregibus… - Current vascular …, 2010 - ingentaconnect.com
The neo-angiogenesis process is crucial for solid tumor growth and invasion, as the
vasculature provides metabolic support and access to the circulation. Tumor blood vessels …

Heterogeneity of tumor endothelial cells and drug delivery

K Hida, N Maishi, Y Sakurai, Y Hida… - Advanced Drug Delivery …, 2016 - Elsevier
To date anti-angiogenic therapy has been used for cancer therapy widely, yielding
promising results. However, it has been elucidated that current anti-angiogenic drug has …

The tumor vascular endothelium as decision maker in cancer therapy

D Klein - Frontiers in oncology, 2018 - frontiersin.org
Genetic and pathophysiologic criteria prearrange the uncontrolled growth of neoplastic cells
that in turn initiates new vessel formation, which is prerequisite for further tumor growth and …

The epigenetic profile of tumor endothelial cells. Effects of combined therapy with antiangiogenic and epigenetic drugs on cancer progression

O Ciesielski, M Biesiekierska, B Panthu… - International journal of …, 2020 - mdpi.com
Tumors require a constant supply of nutrients to grow which are provided through tumor
blood vessels. To metastasize, tumors need a route to enter circulation, that route is also …

Tumor endothelial cells accelerate tumor metastasis

N Maishi, K Hida - Cancer science, 2017 - Wiley Online Library
Tumor metastasis is the main cause of cancer‐related death. Understanding the molecular
mechanisms underlying tumor metastasis is crucial to control this fatal disease. Several …

Tumor exploits alternative strategies to achieve vascularization

B Bussolati, C Grange, G Camussi - The FASEB Journal, 2011 - Wiley Online Library
Neoangiogenesis is crucial for solid tumor growth and invasion, as the vasculature provides
metabolic support and access to the circulation. Current antiangiogenic therapies have been …