Bacteriophage-antibiotic combinations for Enterococcus faecium with varying bacteriophage and daptomycin susceptibilities

T Morrisette, KL Lev, R Kebriaei… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate
novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are …

Lytic bacteriophages facilitate antibiotic sensitization of Enterococcus faecium

GS Canfield, A Chatterjee, J Espinosa… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
Enterococcus faecium, a commensal of the human intestine, has emerged as a hospital-
adapted, multidrug-resistant (MDR) pathogen. Bacteriophages (phages), natural predators …

Mechanistic Insights Into the Differential Efficacy of Daptomycin Plus β-Lactam Combinations Against Daptomycin-Resistant Enterococcus faecium

R Kebriaei, KC Stamper, KV Singh… - The Journal of …, 2020 - academic.oup.com
Background The combination of daptomycin (DAP) plus ampicillin (AMP), ertapenem (ERT),
or ceftaroline has been demonstrated to be efficacious against a DAP-tolerant Enterococcus …

Evaluation of Bacteriophage-Antibiotic Combination Therapy for Biofilm-Embedded MDR Enterococcus faecium

K Lev, AJ Kunz Coyne, R Kebriaei, T Morrisette… - Antibiotics, 2022 - mdpi.com
Multidrug-resistant (MDR) Enterococcus faecium is a challenging pathogen known to cause
biofilm-mediated infections with limited effective therapeutic options. Lytic bacteriophages …

Phage-antibiotic cocktail rescues daptomycin and phage susceptibility against daptomycin-nonsusceptible Enterococcus faecium in a simulated endocardial …

AJ Kunz Coyne, K Stamper, A El Ghali… - Microbiology …, 2023 - Am Soc Microbiol
Enterococcus faecium is a difficult-to-treat pathogen with emerging resistance to most
clinically available antibiotics. Daptomycin (DAP) is the standard of care, but even high DAP …

Phage Cocktails with Daptomycin and Ampicillin Eradicates Biofilm-Embedded Multidrug-Resistant Enterococcus faecium with Preserved Phage Susceptibility

AJK Coyne, K Stamper, R Kebriaei, DJ Holger… - Antibiotics, 2022 - mdpi.com
Multidrug-resistant (MDR) Enterococcus faecium is a challenging nosocomial pathogen
known to colonize medical device surfaces and form biofilms. Bacterio (phages) may …

Bacteriophage and antibiotic combination therapy for recurrent Enterococcus faecium bacteremia

ME Stellfox, C Fernandes, RK Shields, G Haidar… - Mbio, 2024 - Am Soc Microbiol
Enterococcus faecium is a member of the human gastrointestinal (GI) microbiota but can
also cause invasive infections, especially in immunocompromised hosts. Enterococci …

β-Lactam combinations with daptomycin provide synergy against vancomycin-resistant Enterococcus faecalis and Enterococcus faecium

JR Smith, KE Barber, A Raut… - Journal of …, 2015 - academic.oup.com
Abstract Objectives Enterococcus faecalis (Efc) and Enterococcus faecium (Efm) are
frequently resistant to vancomycin and β-lactams (BLs). In vitro data suggest synergy …

Defeating Antibiotic- and Phage-Resistant Enterococcus faecalis Using a Phage Cocktail in Vitro and in a Clot Model

L Khalifa, D Gelman, M Shlezinger, AL Dessal… - Frontiers in …, 2018 - frontiersin.org
The deteriorating effectiveness of antibiotics is propelling researchers worldwide towards
alternative techniques such as phage therapy: curing infectious diseases using viruses of …

Isolation and characterization of a novel Enterococcus faecalis bacteriophage φEF24C as a therapeutic candidate

J Uchiyama, M Rashel, Y Maeda… - FEMS Microbiology …, 2008 - academic.oup.com
Vancomycin-resistant Enterococcus faecalis (VRE) has become a significant threat in
nosocomial settings. Bacteriophage (phage) therapy is frequently proposed as a potential …